Evidence map›Paper›PMID 26944386›Full record

ArticleThe Journal of international medical research2016

Vitamin D deficiency and related risk factors in patients with diabetic nephropathy.

Xiaoyan Xiao, Yajuan Wang, Yanlian Hou, Feng Han, Jianmin Ren, Zhao Hu

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2020
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Vitamin D and Diabetic Kidney Disease.International journal of molecular sciences · 2023
    Review
  10. Article
  11. The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
  14. NADH/NADBiomolecules · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. 1,25-Dihydroxyvitamin DOncotarget · 2018
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xiaoyan XiaoDepartment of Nephrology, Qilu Hospital of Shandong University, Jinan, China.
Yajuan WangDepartment of Endocrinology, Jinan Central Hospital, Jinan, China Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
Yanlian HouDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
Feng HanDepartment of Endocrinology, Zhangqiu City People's Hospital, Jinan, China.
Jianmin RenDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
Zhao HuDepartment of Nephrology, Qilu Hospital of Shandong University, Jinan, China hz12040813@163.com.
Qilu Hospital of Shandong University · CNJinan Central Hospital · CNZhangqiu City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate serum 25-hydroxyvitamin D (25[OH]D) levels in patients with diabetic nephropathy, analyse the relationship between 25(OH)D and clinical indexes, and identify risk factors for vitamin D deficiency in diabetic nephropathy.

methodsPatients with diabetic nephropathy were sequentially enrolled and grouped according to diabetic nephropathy stage. Serum 25(OH)D levels were measured. A control group of healthy subjects was used for comparison.

resultsOut of 240 patients with diabetic nephropathy and 60 healthy controls, 25(OH)D levels were lower in diabetic nephropathy patients than in controls, and showed a gradually decreasing trend with diabetic nephropathy stage. Serum 25(OH)D levels were significantly correlated with age, sex, diabetes history, body mass index, systolic blood pressure, albumin excretion rate (AER), estimated glomerular filtration rate, fasting blood glucose, glycosylated haemoglobin (HbA1c), haemoglobin, serum albumin, creatinine clearance rate, blood urea nitrogen and complicated diabetic retinopathy. Moreover, age, body mass index, AER, haemoglobin, and HbA1c were independent risk factors of 25(OH)D deficiency in diabetic nephropathy.

conclusionsVitamin D deficiency is prevalent in patients with diabetic nephropathy and increases in severity with diabetic nephropathy progression. Age, obesity, glucose level and renal function largely affect 25(OH)D deficiency in diabetic nephropathy.

Indexed as

Case-Control StudiesDemographyDiabetic NephropathiesFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisRisk FactorsVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D25(OH)Dalbumin excretion ratediabetic kidney diseasetype 2 diabetes

Identifiers

PMID26944386
PMCPMC5536722
OpenAlexW2292076709

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.