ArticleMolecular & cellular proteomics : MCP2016
Natural Genetic Variation Differentially Affects the Proteome and Transcriptome in Caenorhabditis elegans.
Article in Molecular & cellular proteomics : MCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The regulatory architecture of gene expression variation in Caenorhabditis elegans revealed by multi-strain allele-specific analysis.Genetics · 2025Article
- The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025Article
- Detecting gene expression in Caenorhabditis elegans.Genetics · 2025Review
- High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.Cell reports · 2024Article
- High-content phenotypic analysis ofbioRxiv : the preprint server for biology · 2024Article
- Cryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-typeiScience · 2022Article
- The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population.G3 (Bethesda, Md.) · 2021Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
- Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity.BMC genomics · 2019Article
- Inverted repeat structures are associated with essential and highly expressed genes onRNA (New York, N.Y.) · 2018Article
- Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.Cell metabolism · 2018Article
- Use of a Sibling Subtraction Method for Identifying Causal Mutations inG3 (Bethesda, Md.) · 2018Article
- Comparative proteome analysis between C . briggsae embryos and larvae reveals a role of chromatin modification proteins in embryonic cell division.Scientific reports · 2017Article
- Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans.Human genomics · 2017Review
- Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways.PloS one · 2016Article
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14 authors.
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Abstract
Natural genetic variation is the raw material of evolution and influences disease development and progression. An important question is how this genetic variation translates into variation in protein abundance. To analyze the effects of the genetic background on gene and protein expression in the nematode Caenorhabditis elegans, we quantitatively compared the two genetically highly divergent wild-type strains N2 and CB4856. Gene expression was analyzed by microarray assays, and proteins were quantified using stable isotope labeling by amino acids in cell culture. Among all transcribed genes, we found 1,532 genes to be differentially transcribed between the two wild types. Of the total 3,238 quantified proteins, 129 proteins were significantly differentially expressed between N2 and CB4856. The differentially expressed proteins were enriched for genes that function in insulin-signaling and stress-response pathways, underlining strong divergence of these pathways in nematodes. The protein abundance of the two wild-type strains correlates more strongly than protein abundance versus transcript abundance within each wild type. Our findings indicate that in C. elegans only a fraction of the changes in protein abundance can be explained by the changes in mRNA abundance. These findings corroborate with the observations made across species.
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