Evidence map›Paper›PMID 26943940›Full record

ArticleJournal of affective disorders2016

High frequency heart-rate variability predicts adolescent depressive symptoms, particularly anhedonia, across one year.

Lauren Vazquez, Julia D Blood, Jia Wu, Tara M Chaplin, Rebecca E Hommer, Helena J V Rutherford, Marc N Potenza, Linda C Mayes, Michael J Crowley

Abstract read
In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Refined matrix completion for spectrum estimation of heart rate variability.Mathematical biosciences and engineering : MBE · 2024
    Article
  5. Infant emotion regulation in the context of stress: Effects of heart rate variability and temperament.Stress and health : journal of the International Society for the Investigation of Stress · 2024
    Article
  6. Article
  7. Article
  8. Cardiac sympathetic-vagal activity initiates a functional brain-body response to emotional arousal.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
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  16. Article
  17. Article
  18. Inflexibility as a Vulnerability to Depression: A Systematic Qualitative Review.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2017
    Article
  19. Article
  20. Physiological Markers of Interpersonal Stress Generation in Depression.Clinical psychological science : a journal of the Association for Psychological Science · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lauren VazquezYale Child Study Center, Yale School of Medicine, New Haven, CT, USA.
Julia D BloodSchool of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Jia WuYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA.
Tara M ChaplinDepartment of Psychology, George Mason University, Fairfax, VA, USA.
Rebecca E HommerEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Helena J V RutherfordYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA.
Marc N PotenzaYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Neuroscience and CASAColumbia, Yale University School of Medicine, New Haven, CT, USA; Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA; CASAColumbia, Yale University School of Medicine, New Haven, CT, USA.
Linda C MayesYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA.
Michael J CrowleyYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Program for Anxiety Disorders, Yale Child Study Center, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA. Electronic address: michael.crowley@yale.edu.

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
REGULATION OF AROUSAL AND ATTENTION IN COCAINE EXPOSEDR01DA006025 · NIDA · YALE UNIVERSITY · PI MAYES, LINDA CAROL · 1992 to 2007
$6.0M
Cocaine-Exposed Children & Event Related Potential Studies of NeurocognitionR01DA017863 · NIDA · YALE UNIVERSITY · PI MAYES, LINDA CAROL · 2004 to 2008
$1.7M
Interdisciplinary Research on Stress, Self-Control & AddictionUL1RR024925 · NCRR · YALE UNIVERSITY · PI SINHA, RAJITA · 2007 to 2007
$849k
Neural Correlates of Negative Reinforcement in Adolescence & Substance Use RiskK01DA034125 · NIDA · YALE UNIVERSITY · PI CROWLEY, MICHAEL J · 2012 to 2016
$823k
NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1RR024139NCRR NIH HHS UL1 RR024925NCRR NIH HHS UL1RR024925-01NIDA NIH HHS DA-017863NIDA NIH HHS K01 DA034125NIDA NIH HHS K01-DA034125NIDA NIH HHS R01 DA006025NIDA NIH HHS R01 DA017863NIDA NIH HHS R01-DA-06025
6 · The paper itself

Abstract

backgroundFew prospective studies examine the link between lower heart rate variability (HRV) and depression symptoms in adolescents. A recent animal model specifically links HRV to anhedonia, suggesting a potential translational model for human research.

methodWe investigated the association between spectral measures of resting HRV and depressive symptoms measured one year later, among 73 adolescents, aged 11-18 years. We evaluated (1) the predictive power of relative high frequency (HF) HRV, relative low frequency (LF) and relative very low frequency (VLF) HRV for depressive symptoms; and (2) the relative strength of association between HF HRV and depressive symptomatology (anhedonia, negative mood, interpersonal problems, ineffectiveness, negative self-esteem).

resultsHF HRV significantly predicted self-reported depressive symptoms across one year, controlling for age, puberty and sex. HF HRV was most strongly associated with anhedonia one year later, after considering other facets of depressive symptomatology.

conclusionsResults provide support for the prospective relationship between relative HF HRV and depressive symptoms among adolescents across one year. Findings concur with rodent models that suggest a specific link between HF HRV and anhedonia. LIMITATIONS: We investigated relative spectral power HF HRV and depressive symptom dimensions. We cannot make strong claims about these associations in clinical depression. Physical activity levels could be controlled in future work.

Indexed as

AffectAnhedoniaDepressionHeart RateAdolescentFemaleHumansMaleProspective StudiesSexual MaturationAdolescenceAnhedoniaDepressionHeart rate variabilityTime-frequency analysis

Identifiers

PMID26943940
PMCPMC4844545

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.