ArticleOncotarget2016
Improved muscle function and quality after diet intervention with leucine-enriched whey and antioxidants in antioxidant deficient aged mice.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Antioxidant Interventions on Muscle Function and Mass in Aging-Related Muscle Decline: A Systematic Review of Preclinical and Clinical Evidence.Antioxidants (Basel, Switzerland) · 2026Review
- Association of Dietary Antioxidant Potential with Sarcopenia in Hypertension.Reviews in cardiovascular medicine · 2025Article
- Muscle Protein Synthesis with a Hybrid Dairy and Plant-Based Protein Blend (P4) Is Equal to Whey Protein in a Murine Ageing Model after Fasting.Nutrients · 2023Article
- Moderate to vigorous physical activity, leucine, and protein intake contributions to muscle health in middle age.Journal of frailty, sarcopenia and falls · 2022Article
- Whey Proteins-Fortified Milk with Adjusted Casein to Whey Proteins Ratio Improved Muscle Strength and Endurance Exercise Capacity without Lean Mass Accretion in Rats.Foods (Basel, Switzerland) · 2022Article
- Effects of whole-body vibration training in a cachectic C26 mouse model.Scientific reports · 2021Article
- Correlation of oxidative stress-related indicators with milk composition and metabolites in early lactating dairy cows.Veterinary medicine and science · 2021Article
- Whey for Sarcopenia; Can Whey Peptides, Hydrolysates or Proteins Play a Beneficial Role?Foods (Basel, Switzerland) · 2020Review
- Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle.Scientific reports · 2020Article
- Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia.Aging and disease · 2019Review
- Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice.Journal of cachexia, sarcopenia and muscle · 2018Article
- Sarcopenia, Aging and Prospective Interventional Strategies.Current medicinal chemistry · 2018Review
- A New Model of Diarrhea with Spleen-Kidney Yang Deficiency Syndrome.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice.Molecular nutrition & food research · 2017Article
- Impact of exudative diathesis induced by selenium deficiency on LncRNAs and their roles in the oxidative reduction process in broiler chick veins.Oncotarget · 2017Article
- Whey Protein Improves Marathon-Induced Injury and Exercise Performance in Elite Track Runners.International journal of medical sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antioxidant (AOX) deficiencies are commonly observed in older adults and oxidative stress has been suggested to contribute to sarcopenia. Here we investigate if 1) low levels of dietary antioxidants had a negative impact on parameters of muscle mass, function and quality, and 2) to study if nutritional interventions with AOX and/or leucine-enriched whey protein could improve these muscle parameters in aged mice. 18-months-old mice were fed a casein-based antioxidant-deficient (lowox) diet or a casein-based control-diet (CTRL) for 7 months. During the last 3 months, lowox-mice were subjected to either: a) continued lowox, b) supplementation with vitamin A/E, Selenium and Zinc (AOX), c) substitution of casein with leucine-enriched whey protein (PROT) or d) a combination of both AOX and PROT (TOTAL). After 7 months lowox-mice displayed lower muscle strength and more muscle fatigue compared to CTRL. Compared to lowox-mice, PROT-mice showed improved muscle power, grip strength and less muscle fatigue. AOX-mice showed improved oxidative status, less muscle fatigue, improved grip strength and mitochondrial dynamics compared to lowox-mice. The TOTAL-mice showed the combined effects of both interventions compared to lowox-mice. In conclusion, nutritional intervention with AOX and/or leucine-enriched whey protein can play a role in improving muscle health in a AOX-deficient mouse model.
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Registered trials
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