Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016
The Impact of Sleep Debt on Excess Adiposity and Insulin Sensitivity in Patients with Early Type 2 Diabetes Mellitus.
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.Frontiers in endocrinology · 2024Trial
- Trial
- Regulating Effect of Weekend Catch-up Sleep on Association of Hepatic Steatosis with Atherosclerotic Cardiovascular Disease.Balkan medical journal · 2025Article
- Misalignment Between Circadian Preference and Accelerometer-Derived Sleep-Wake Cycle With Increased Risk of Cardiometabolic Diseases.JACC. Advances · 2024Article
- International dietary quality index and its association with diabetes in RaNCD cohort study.Scientific reports · 2024Article
- The Relationship between Sleep and Physical Activity by Age, Race, and Gender.Reviews in cardiovascular medicine · 2024Review
- The association of self-reported sleep and circadian measures with glycemic control and diabetes complications among young adults with type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2024Article
- Causal association between sleep traits and the risk of coronary artery disease in patients with diabetes.Frontiers in cardiovascular medicine · 2023Article
- Article
- Sweet dreams: therapeutic insights, targeting imaging and physiologic evidence linking sleep, melatonin and diabetic nephropathy.Clinical kidney journal · 2020Review
- Sleepless in Beirut: sleep duration and associated subjective sleep insufficiency, daytime fatigue, and sleep debt in an urban environment.Sleep & breathing = Schlaf & Atmung · 2020Article
- Sleep debt and prevalence of proteinuria in subjects with short sleep duration on weekdays: a cross-sectional study.Clinical and experimental nephrology · 2020Article
- Sleep debt: the impact of weekday sleep deprivation on cardiovascular health in older women.Sleep · 2019Article
- Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease.Sleep medicine · 2018Article
- A brief review about melatonin, a pineal hormone.Archives of endocrinology and metabolism · 2018Review
- The Amygdala, Sleep Debt, Sleep Deprivation, and the Emotion of Anger: A Possible Connection?Cureus · 2018Review
- Poor Sleep Quality is Associated with Insulin Resistance in Postmenopausal Women With and Without Metabolic Syndrome.Metabolic syndrome and related disorders · 2018Article
- The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy.International journal of endocrinology · 2018Review
- Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study.Journal of women's health (2002) · 2017Article
- Melatonin, mitochondria, and the metabolic syndrome.Cellular and molecular life sciences : CMLS · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
STUDY
objectivesWe examined cross-sectional and prospective associations between sleep debt and adiposity measures, as well as homeostatic model assessment-insulin resistance (HOMA-IR) in early type 2 diabetes.
methodsProspective data analysis from participants of a randomized controlled trial based on an intensive lifestyle intervention (usual care, diet, or diet and physical activity). Data were collected at baseline, 6 months, and 12 months post-intervention. The study was performed across five secondary care centers in the United Kingdom. Patients (n = 593) with a recent diagnosis of type 2 diabetes were recruited. Objective height and weight were ascertained for obesity status (body mass index [BMI]; ≥ 30 kg/m(2)), waist circumference (cm) for central adiposity, and fasting blood samples drawn to examine insulin resistance (IR). Seven-day sleep diaries were used to calculate weekday sleep debt at baseline, calculated as average weekend sleep duration minus average weekday sleep duration.
resultsAt baseline, compared to those without weekday sleep debt, those with weekday sleep debt were 72% more likely to be obese (OR = 1.72 [95% CI:1.03-2.88]). At six months, weekday sleep debt was significantly associated with obesity and IR after adjustment, OR = 1.90 (95% CI:1.10-3.30), OR = 2.07 (95% CI:1.02-4.22), respectively. A further increase at 12 months was observed for sleep debt with obesity and IR: OR = 2.10 (95% CI:1.14-3.87), OR = 3.16 (95% CI:1.38-7.24), respectively. For every 30 minutes of weekday sleep debt, the risk of obesity and IR at 12 months increased by 18% and 41%, respectively.
conclusionsSleep debt resulted in long-term metabolic disruption, which may promote the progression of type 2 diabetes in newly diagnosed patients. Sleep hygiene/education could be an important factor for future interventions to target early diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.