ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2016
Hyaluronidase decreases neutrophils infiltration to the inflammatory site.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- The clinical evidence and strategic use of hyaluronidase in spinal interventions.Anesthesia and pain medicine · 2026Review
- Hyaluronidase treatment is associated with increased cytokine levels and reduced peritoneal neutrophil accumulation during LPS-induced inflammation.Frontiers in pharmacology · 2026Article
- Removal of the endothelial surface layer via hyaluronidase does not modulate monocyte and neutrophil interactions with the glomerular endothelium.Microcirculation (New York, N.Y. : 1994) · 2023Article
- Antiulcerogenic Potential of the Ethanolic Extract ofInternational journal of molecular sciences · 2022Article
- Efficacy of submucosal injection of hyaluronidase after mandibular third molar surgery: a randomized controlled trial.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Article
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- Active Expression of Human Hyaluronidase PH20 and Characterization of Its Hydrolysis Pattern.Frontiers in bioengineering and biotechnology · 2022Article
- Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study.Intensive care medicine experimental · 2021Article
- Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2021Article
- Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs.Journal of immunology research · 2021Article
- Immunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the in vivo anti-inflammatory potential of bovine hyaluronidase (HYAL) using two different models of acute inflammation.
methodsAir pouches were produced in the dorsal subcutaneous of mice and injected with phosphate saline solution or HYAL. The antiinflammatory action of HYAL was evaluated in carrageenan (Cg)-inflamed air pouches. After 4 and 24 h the cellular influx, protein exudation, cytokines and lipid mediators were evaluated. The action of HYAL on the rolling and adhesion of leukocytes was investigated in the LPS-stimulated mesenteric microcirculation by intravital microscopic.
resultsTreatment with HYAL reduced the cellular influx and protein exudation in non-inflamed and inflamed air pouches. HYAL treatment of Cg-inflamed air pouch reduced the production of tumor necrosis factor-alpha (TNF-α), interleukin-8 (IL-8), leukotriene B4 (LTB4) and LTC4, whereas prostaglandins E2 (PGE2) and D2 (PGD2) concentrations were unchanged. Histological analyses showed that HYAL administration diminished cell infiltration in the air-pouch lining. In LPS-stimulated mesenteric microcirculation, HYAL usage decreased rolling and adhesion of leukocytes, but did not affect the blood vessels diameters.
conclusionThe results demonstrate that HYAL inhibited cellular recruitment, edema formation and pro-inflammatory mediators production, resulting in decreased adherence of leukocytes to blood vessels and tissue infiltration. Our data suggest that HYAL may be considered an effective candidate to ameliorate acute inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.