ArticleThe ISME journal2016
Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of theMicrobial genomics · 2022Pooled it
- 4-Aminobenzoic acid attenuatesVirulence · 2026Article
- The Gti1/Pac2 family protein CFG1 controls fungal chlamydospore formation through orchestrating cell wall remodeling, lipid metabolism, and ribosome biogenesis.Applied and environmental microbiology · 2026Article
- Article
- Analysis of Bacterial Wilt Management Strategies From the Dynamic Perspective of Environmental Adaptation Approaches of Ralstonia solanacearum.Environmental microbiology reports · 2026Review
- EngineeringAIMS microbiology · 2026Review
- Endosymbiotic interactions in the fungal kingdom: a framework for progressive endosymbiosis.Frontiers in microbiology · 2026Review
- Hidden Allies: Decoding the Core Endohyphal Bacteriome of Aspergillus fumigatus.Environmental microbiology reports · 2025Article
- Endofungal bacteria as hidden facilitators of biotic interactions.The ISME journal · 2025Review
- Symbioses between fungi and bacteria: from mechanisms to impacts on biodiversity.Current opinion in microbiology · 2024Review
- N-acyl homoserine lactone cell-cell diffusible signalling in the Ralstonia solanacearum species complex.Molecular plant pathology · 2024Review
- Imaging Mass Spectrometry and Genome Mining Reveal Antimicrobial Peptides of NovelFoods (Basel, Switzerland) · 2024Article
- Plant-microbe interactions through a lens: tales from the mycorrhizosphere.Annals of botany · 2024Review
- Putative Role of Anti-microbial Peptide Recovered from Lactiplantibacillus spp. in Biocontrol Activity.Current microbiology · 2024Article
- Does regulation hold the key to optimizing lipopeptide production inFrontiers in bioengineering and biotechnology · 2024Review
- Klebsiella michiganensis: a nitrogen-fixing endohyphal bacterium from Ustilago maydis.AMB Express · 2023Article
- Article
- Quorum Sensing-Dependent Invasion of Ralstonia solanacearum into Fusarium oxysporum Chlamydospores.Microbiology spectrum · 2023Article
- Article
- Proposal to classifyFrontiers in microbiology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Ralstonia solanacearum is a globally distributed soil-borne plant pathogenic bacterium, which shares a broad ecological range with many plant- and soil-associated fungi. We sought to determine if R. solanacearum chemical communication directs symbiotic development of polymicrobial consortia. R. solanacearum produced a diffusible metabolite that induced conserved morphological differentiation in 34 species of fungi across three diverse taxa (Ascomycetes, Basidiomycetes and Zygomycetes). Fungi exposed to this metabolite formed chlamydospores, survival structures with thickened cell walls. Some chlamydospores internally harbored R. solanacearum, indicating a newly described endofungal lifestyle for this important plant pathogen. Using imaging mass spectrometry and peptidogenomics, we identified an undescribed lipopeptide, ralsolamycin, produced by an R. solanacearum non-ribosomal peptide synthetase-polyketide synthase hybrid. Inactivation of the hybrid non-ribosomal peptide synthetase-polyketide synthase gene, rmyA, abolished ralsolamycin synthesis. R. solanacearum mutants lacking ralsolamycin no longer induced chlamydospore development in fungal coculture and invaded fungal hyphae less well than wild-type. We propose that ralsolamycin contributes to the invasion of fungal hyphae and that the formation of chlamydospores may provide not only a specific niche for bacterial colonization but also enhanced survival for the partnering fungus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.