Evidence map›Paper›PMID 26943471›Full record

ArticleSleep2016

Aberrant Insular Functional Network Integrity in Patients with Obstructive Sleep Apnea.

Bumhee Park, Jose A Palomares, Mary A Woo, Daniel W Kang, Paul M Macey, Frisca L Yan-Go, Ronald M Harper, Rajesh Kumar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bumhee ParkDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, CA.
Jose A PalomaresDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, CA.
Mary A WooUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA.
Daniel W KangDepartment of Medicine, University of California at Los Angeles, Los Angeles, CA.
Paul M MaceyUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA.
Frisca L Yan-GoDepartment of Neurology, University of California at Los Angeles.
Ronald M HarperThe Brain Research Institute, University of California at Los Angeles, Los Angeles, CA.
Rajesh KumarDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, CA.
University of California, Los Angeles · US

Funding

Blood-Brain Barrier Deficit and Brain Injury in Obstructive Sleep ApneaR01NR015038 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2015 to 2018
$2.0M
Brain Axonal Injury in Obstructive Sleep ApneaR01HL113251 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL113251NINR NIH HHS R01 NR015038
6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) is accompanied by tissue injury to the insular cortices, areas that regulate autonomic pain, dyspnea, and mood, all of which are affected in the syndrome. Presumably, the dysregulation of insular-related functions are mediated by aberrant functional connections with other brain regions; however, the integrity of the functional connectivity (FC) to other sites is undescribed. Our aim was to examine resting-state FC of the insular cortices to other brain areas in OSA, relative to control subjects.

methodsWe collected resting-state functional magnetic resonance imaging (MRI) data from 67 newly diagnosed, treatment-naïve OSA and 75 control subjects using a 3.0-Tesla MRI scanner. After standard processing, data were analyzed for the left and right insular FC.

resultsOSA subjects showed complex aberrant insular FC to several brain regions, including frontal, parietal, cingulate, temporal, limbic, basal ganglia, thalamus, occipital, cerebellar, and brainstem regions. Areas of altered FC in OSA showed linear relationships with magnitudes of sleep related and neuropsychologic-related variables, whereas control subjects showed no such relationships with those measures.

conclusionsBrain functional connections from insular sites to other brain regions in OSA subjects represent abnormal autonomic, affective, sensorimotor, and cognitive control networks that may affect both impaired parasympathetic and sympathetic interactions, as well as abnormal sensorimotor integration, affected in the condition. The functional changes likely result from the previously reported structural changes in OSA subjects, as demonstrated by diverse neuroimaging studies.

Indexed as

AdultAgedAutonomic Nervous SystemBrain MappingCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSensorimotor CortexSleepSleep Apnea, Obstructiveautonomic regulationfunctional magnetic resonance imagingresting-state functional connectivitysleep disordered breathing

Identifiers

PMID26943471
PMCPMC4835320
OpenAlexW2345093062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.