ArticleSleep2016
Regional Patterns of Elevated Alpha and High-Frequency Electroencephalographic Activity during Nonrapid Eye Movement Sleep in Chronic Insomnia: A Pilot Study.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 116 citations in OpenAlex.
- Acute Effects of Oral Cannabinoids on Sleep and High-Density EEG in Insomnia: A Pilot Randomised Controlled Trial.Journal of sleep research · 2026Trial
- A randomized controlled trial of alpha phase-locked auditory stimulation to treat symptoms of sleep onset insomnia.Scientific reports · 2024Trial
- Insomnia Symptoms in a Swiss Population-Based Cohort: Prevalence, Clinical Correlates and Polysomnographic Alterations.Journal of sleep research · 2026Article
- Epigenetic Insights and Exosome-Based Therapeutics for Insomnia: Bridging Sleep Biology and Precision Medicine.Molecular neurobiology · 2026Review
- Impaired sleep resilience underlies transient neural instability in insomnia disorder.iScience · 2026Article
- Article
- Association among objective and subjective sleep duration, depressive symptoms and all-cause mortality: the pathways study.BMC psychiatry · 2025Article
- Multimodal assessment of sleep-wake perception in insomnia disorder.Scientific reports · 2025Article
- EEG spectral analysis of nighttime sleep and daytime MSLTs and neurocognitive evaluations in subjects with co-morbid insomnia and OSA.Respiratory research · 2025Article
- A continuous approach to explain insomnia and subjective-objective sleep discrepancy.Communications biology · 2025Article
- Revolutionizing Sleep Science: A Narrative Review of the Historical Origins and Current Applications of Sleep Neuroimaging.Nature and science of sleep · 2025Review
- A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention.Heliyon · 2024Article
- Article
- Neurophysiological Parameters Influencing Sleep-Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset.Brain sciences · 2024Article
- Effect of closed-loop vibration stimulation on sleep quality for poor sleepers.Frontiers in neuroscience · 2024Article
- Restoration of abnormal sleep EEG power in patients with insomnia disorder after 1Hz rTMS over left DLPFC.Frontiers in psychiatry · 2024Article
- Wavelet Entropy Analysis of Electroencephalogram Signals During Wake and Different Sleep Stages in Patients with Insomnia Disorder.Nature and science of sleep · 2024Article
- Beta spectral power during sleep is associated with impaired recall of extinguished fear.Sleep · 2023Article
- Core body temperature changes before sleep are associated with nocturnal heart rate variability.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The sleep and wake electroencephalogram over the lifespan.Neurobiology of aging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTo examine nonrapid eye movement (NREM) sleep in insomnia using high-density electroencephalography (EEG).
methodsAll-night sleep recordings with 256 channel high-density EEG were analyzed for 8 insomnia subjects (5 females) and 8 sex and age-matched controls without sleep complaints. Spectral analyses were conducted using unpaired t-tests and topographical differences between groups were assessed using statistical non-parametric mapping. Five minute segments of deep NREM sleep were further analyzed using sLORETA cortical source imaging.
resultsThe initial topographic analysis of all-night NREM sleep EEG revealed that insomnia subjects had more high-frequency EEG activity (> 16 Hz) compared to good sleeping controls and that the difference between groups was widespread across the scalp. In addition, the analysis also showed that there was a more circumscribed difference in theta (4-8 Hz) and alpha (8-12 Hz) power bands between groups. When deep NREM sleep (N3) was examined separately, the high-frequency difference between groups diminished, whereas the higher regional alpha activity in insomnia subjects persisted. Source imaging analysis demonstrated that sensory and sensorimotor cortical areas consistently exhibited elevated levels of alpha activity during deep NREM sleep in insomnia subjects relative to good sleeping controls.
conclusionsThese results suggest that even during the deepest stage of sleep, sensory and sensorimotor areas in insomnia subjects may still be relatively active compared to control subjects and to the rest of the sleeping brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.