ArticleDevelopmental cognitive neuroscience2016
Neural correlates of self-perceptions in adolescents with major depressive disorder.
Article in Developmental cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Ibudilast attenuates alcohol cue-elicited frontostriatal functional connectivity in alcohol use disorder.Alcoholism, clinical and experimental research · 2021Trial
- The diverse relationship between self-prioritization effect and emotional valence: Self-positivity bias and self-negative repulsion.Cognitive, affective & behavioral neuroscience · 2026Article
- Self-Processing Circuits Among Depressed Youth After Amygdala Neurofeedback Cued to the Self-Face.Journal of neuroscience research · 2025Article
- Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.Psychiatry research. Neuroimaging · 2025Review
- Neural activity during negative self-evaluation is associated with negative self-concept and depressive symptoms in adolescent girls.Development and psychopathology · 2025Article
- Depicting Coupling Between Cortical Morphology and Functional Networks in Major Depressive Disorder.Depression and anxiety · 2025Article
- Self-compassion, self-referential caudate circuitry, and adolescent suicide ideation.Translational psychiatry · 2024Article
- Vulnerable brain regions in adolescent major depressive disorder: A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis.World journal of psychiatry · 2024Article
- Self-compassion and dorsolateral prefrontal cortex activity during sad self-face recognition in depressed adolescents.Psychological medicine · 2022Article
- Self-evaluation as an active ingredient in the experience and treatment of adolescent depression; an integrated scoping review with expert advisory input.BMC psychiatry · 2021Article
- Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.Frontiers in psychiatry · 2021Review
- Correlates of C-reactive protein with neural reward circuitry in adolescents with psychiatric symptoms.Brain, behavior, & immunity - health · 2020Article
- Depressogenic self-schemas are associated with smaller regional grey matter volume in never-depressed preadolescents.NeuroImage. Clinical · 2020Article
- 'I Am Worthless and Kind'; the specificity of positive and negative self-evaluation in adolescent depression.The British journal of clinical psychology · 2019Article
- Review of Abnormal Self-Knowledge in Major Depressive Disorder.Frontiers in psychiatry · 2019Review
- The Development of Self and Identity in Adolescence: Neural Evidence and Implications for a Value-Based Choice Perspective on Motivated Behavior.Child development perspectives · 2018Article
- Dorsomedial Prefrontal Activity to Sadness Predicts Later Emotion Suppression and Depression Severity in Adolescent Girls.Child development · 2018Article
- The neurobiology of self face recognition among depressed adolescents.Journal of affective disorders · 2018Article
- Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Alteration in self-perception is a salient feature in major depression. Hyperactivity of anterior cortical midline regions has been implicated in this phenomenon in depressed adults. Here, we extend this work to depressed adolescents during a developmental time when neuronal circuitry underlying the sense of self matures by using task-based functional magnetic resonance imaging (fMRI) and connectivity analyses. Twenty-three depressed adolescents and 18 healthy controls (HC) viewed positive and negative trait words in a scanner and judged whether each word described them ('self' condition) or was a good trait to have ('general' condition). Self-perception scores were based on participants' endorsements of positive and negative traits during the fMRI task. Depressed adolescents exhibited more negative self-perceptions than HC. Both groups activated cortical midline regions in response to self-judgments compared to general-judgments. However, depressed adolescents recruited the posterior cingulate cortex/precuneus more for positive self-judgments. Additionally, local connectivity of the dorsal medial prefrontal cortex was reduced during self-reflection in depressed adolescents. Our findings highlight differences in self-referential processing network function between depressed and healthy adolescents and support the need for further investigation of brain mechanisms associated with the self, as they may be paramount to understanding the etiology and development of major depressive disorder.
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