ArticleEndocrinology2016
Peripubertal Stress With Social Support Promotes Resilience in the Face of Aging.
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Impact of early life adversity and tryptophan depletion on functional connectivity in menopausal women: A double-blind, placebo-controlled crossover study.Psychoneuroendocrinology · 2017Trial
- Stress during puberty and adulthood pregnancy impact histone acetylation regulators in the hypothalamus.Neuroscience · 2025Article
- Early life stress and altered social behaviors: A perspective across species.Neuroscience research · 2025Review
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.bioRxiv : the preprint server for biology · 2024Article
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.Stress (Amsterdam, Netherlands) · 2024Article
- Social aging trajectories are sex-specific, sensitive to adolescent stress, and most robustly revealed during social tests with familiar stimuli.bioRxiv : the preprint server for biology · 2023Article
- Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
- MicroRNA Regulates Early-Life Stress-Induced Depressive Behavior via Serotonin Signaling in a Sex-Dependent Manner in the Prefrontal Cortex of Rats.Biological psychiatry global open science · 2021Article
- Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats.Epigenomics · 2021Article
- Chronic adolescent stress causes sustained impairment of cognitive flexibility and hippocampal synaptic strength in female rats.Neurobiology of stress · 2021Article
- Animal models built for women's brain health: Progress and potential.Frontiers in neuroendocrinology · 2020Review
- Impact of childhood adversity on network reconfiguration dynamics during working memory in hypogonadal women.Psychoneuroendocrinology · 2020Article
- Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior.Molecular psychiatry · 2020Review
- Sex Differences in Vulnerability and Resilience to Stress Across the Life Span.Biological psychiatry · 2019Review
- Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice.Chinese medical journal · 2019Article
- Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.Molecular psychiatry · 2018Article
- Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.Biological psychiatry · 2017Article
- Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition.The Journal of clinical psychiatry · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The peripubertal period of development is a sensitive window, during which adverse experiences can increase the risk for presentation of cognitive and affective dysfunction throughout the lifespan, especially in women. However, such experiences in the context of a supportive social environment can actually ameliorate this risk, suggesting that resilience can be programmed in early life. Affective disorders and cognitive deficits commonly emerge during aging, with many women reporting increased difficulty with prefrontal cortex (PFC)-dependent executive functions. We have developed a mouse model to examine the interaction between peripubertal experience and age-related changes in cognition and stress regulation. Female mice were exposed to peripubertal chronic stress, during which they were either individually housed or housed with social interaction. One year after this stress experience, mice were examined in tasks to access their cognitive ability and flexibility in stress reactive measures. In a test of spatial memory acquisition and reversal learning where aged females normally display a decreased performance, the females that had experienced stress with social interaction a year earlier showed improved performance in reversal learning, a measure of cognitive flexibility. Because peripuberty is a time of major PFC maturation, we performed transcriptomic and biochemical analysis of the aged PFC, in which long-term changes in microRNA expression and in myelin proteins were found. These data suggest that stress in the context of social support experienced over the pubertal window can promote epigenetic reprogramming in the brain to increase the resilience to age-related cognitive decline in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.