ArticlePloS one2016
The Tomato Hoffman's Anthocyaninless Gene Encodes a bHLH Transcription Factor Involved in Anthocyanin Biosynthesis That Is Developmentally Regulated and Induced by Low Temperatures.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 150 citations in OpenAlex.
- Loss of DET1 in High Pigment 2 Tomato Prevents High Temperature Repression of Anthocyanin Biosynthesis in Fruit Through HY5 Stabilization.Plant, cell & environment · 2026Article
- Spatial control of anthocyanin and proanthocyanidin production in tomato fruits by competitive MBW complexes to promote seed dispersal.Plant communications · 2026Article
- Melatonin and Brassinolide Enhance Cold Tolerance inPlants (Basel, Switzerland) · 2026Article
- Two mutations in the same MYC-bHLH transcription factor cause segregation of purple coloration of stolons and seed heads inHorticulture research · 2025Article
- Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops.Horticulture research · 2025Article
- Article
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- Effects of different straw breeding substrates on the growth of tomato seedlings and transcriptome analysis.Scientific reports · 2024Article
- Regulation of Anthocyanin Accumulation in TomatoPlants (Basel, Switzerland) · 2024Article
- Genetic and Biotechnological Approaches to Improve Fruit Bioactive Content: A Focus on Eggplant and Tomato Anthocyanins.International journal of molecular sciences · 2024Review
- Integrated transcriptome and metabolome analysis reveals anthocyanin biosynthesis mechanisms in pepper (Capsicum annuum L.) leaves under continuous blue light irradiation.BMC plant biology · 2024Article
- Candidate Gene Identification and Transcriptome Analysis of TomatoInternational journal of molecular sciences · 2024Article
- Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness.Biomedicines · 2024Review
- Transcriptional regulation of tomato fruit ripening.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- A putative E3 ubiquitin ligase substrate receptor degrades transcription factor SmNAC to enhance bacterial wilt resistance in eggplant.Horticulture research · 2024Article
- Molecular switches in plant stress adaptation.Molecular biology reports · 2023Review
- Association Analysis of Transcriptome and Targeted Metabolites Identifies Key Genes Involved inInternational journal of molecular sciences · 2023Article
- Beyond green and red: unlocking the genetic orchestration of tomato fruit color and pigmentation.Functional & integrative genomics · 2023Review
- Novel R2R3 MYB transcription factors regulate anthocyanin synthesis in Aubergine tomato plants.BMC plant biology · 2023Article
- Biased pollen transfer by bumblebees favors the paternity of virus-infected plants in cross-pollination.iScience · 2023Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anthocyanin pigments play many roles in plants, including providing protection against biotic and abiotic stresses. Many of the genes that mediate anthocyanin accumulation have been identified through studies of flowers and fruits; however, the mechanisms of genes involved in anthocyanin regulation in seedlings under low-temperature stimulus are less well understood. Genetic characterization of a tomato inbred line, FMTT271, which showed no anthocyanin pigmentation, revealed a mutation in a bHLH transcription factor (TF) gene, which corresponds to the ah (Hoffman's anthocyaninless) locus, and so the gene in FMTT271 at that locus was named ah. Overexpression of the wild type allele of AH in FMTT271 resulted in greater anthocyanin accumulation and increased expression of several genes in the anthocyanin biosynthetic pathway. The expression of AH and anthocyanin accumulation in seedlings was shown to be developmentally regulated and induced by low-temperature stress. Additionally, transcriptome analyses of hypocotyls and leaves from the near-isogenic lines seedlings revealed that AH not only influences the expression of anthocyanin biosynthetic genes, but also genes associated with responses to abiotic stress. Furthermore, the ah mutation was shown to cause accumulation of reactive oxidative species and the constitutive activation of defense responses under cold conditions. These results suggest that AH regulates anthocyanin biosynthesis, thereby playing a protective role, and that this function is particularly important in young seedlings that are particularly vulnerable to abiotic stresses.
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