Evidence map›Paper›PMID 26942879›Full record

ArticleOncotarget2016

Lnc-SGK1 induced by Helicobacter pylori infection and highsalt diet promote Th2 and Th17 differentiation in human gastric cancer by SGK1/Jun B signaling.

Yongliang Yao, Qingbo Jiang, Lixing Jiang, Jianhong Wu, Qinghui Zhang, Jianjun Wang, Huang Feng, Panpan Zang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 71 citations in OpenAlex.

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  8. Implications of lncRNAs inFrontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yongliang YaoDepartment of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Qingbo JiangDepartment of Clinical Laboratory, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China.
Lixing JiangDepartment of Clinical Laboratory, Wujin Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu, China.
Jianhong WuDepartment of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Qinghui ZhangDepartment of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Jianjun WangDepartment of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Huang FengDepartment of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Panpan ZangDepartment of Clinical Laboratory, The First People's Hospital of Kunshan, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Jiangsu University · CNFirst People's Hospital of Kunshan · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum and glucocorticoid-inducible kinase (SGK) 1can be triggered in several malignancies. Most research on SGK1has focused on its role in cancer cells, and we sought to investigate its potential upstream non-coding RNA nominated as Lnc-SGK1, and their expression and diagnostic value in T cells in human gastric cancer (GC). Excessive expression of Lnc-SGK1 and SGK1 were observed in T cell either within the tumor or peripheral T cells, and furthermore associated with Helicobacter pylori infection and high-salt diet (HSD). Within T cells, Helicobacter pylori (Hp) infection and high-salt dietcan up-regulated SGK1 expression and in turn enhance expression of Lnc-SGK1 through JunB activation. And expression of Lnc-SGK1 can further enhance transcription of SGK1 through cis regulatory mode. Lnc-SGK1 can induce Th2 and Th17 and reduce Th1 differentiation via SGK1/JunB signaling. Serum Lnc-SGK1 expression in combination with H. pylori infection and/or HSD in T cells was associated with poor prognosis of GC patients, and could be an ideal diagnostic index in human GC.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCase-Control StudiesCell DifferentiationCells, CulturedFemaleFollow-Up StudiesGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansImmediate-Early ProteinsLymphatic MetastasisMaleBiomarkers, TumorImmediate-Early ProteinsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-junRNA, UntranslatedSerum-Glucocorticoid Regulated KinasesSodium Chloride, Dietarygastric cancerHelicobacter pylori infectionhigh-salt dietLncRNAserum and glucocorticoid-inducible kinase

Identifiers

PMID26942879
PMCPMC4991474
OpenAlexW2290235500

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.