Evidence map›Paper›PMID 26942594›Full record

ArticleInternational urogynecology journal2016

Effects of cannabinoid receptor activation by CP55,940 on normal bladder function and irritation-induced bladder overactivity in non-awake anaesthetised rats.

Evangelia Bakali, Yvonne Mbaki, David G Lambert, Ruth A Elliott, Robert Mason, Douglas G Tincello

Abstract read
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In one paragraph

Article in International urogynecology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Current pharmacotherapy of overactive bladder.International braz j urol : official journal of the Brazilian Society of Urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Evangelia BakaliDepartment of Health Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, PO Box 65, Leicester, LE2 7LX, UK. evibakali@me.com.
Yvonne MbakiSchool of Life Sciences, University of Nottingham, Nottingham, UK.
David G LambertDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Ruth A ElliottDepartment of Health Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, PO Box 65, Leicester, LE2 7LX, UK.
Robert MasonSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Douglas G TincelloDepartment of Health Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, PO Box 65, Leicester, LE2 7LX, UK.
University of Leicester · GBUniversity of Nottingham · GBLeicester Royal Infirmary · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisThis study was designed to evaluate the effects of CP55,940 on normal bladder function in vivo and examine whether it suppresses urinary frequency induced by nociceptive stimuli in the bladder. Cannabinoid receptor (CBR) activity may be involved in the regulation of bladder function. However, the role of CBR subtypes in micturition has yet to be established. CP55,940 is a synthetic analogue of tetrahydrocannabidiol, which is a psychoactive ingredient of the Cannabis plant.

methodsCystometry under urethane anaesthesia was performed to evaluate the effect of intravesical delivery of CP55,940 with or without administration of CB1 antagonist AM251 or CB2 antagonist AM630 on bladder function in female rats. The effects of CP55,940 were also examined in rats with urinary irritation induced by intravesical infusion of acetic acid.

resultsInfusion of CP55,940 significantly (p < 0.05) increased micturition interval (MI) and bladder capacity (BC) by 52 % and decreased maximal voiding pressure (MP) by 25 %. Pretreatment with AM251 or AM630 before CP55,940 administration prevented CP55,940-induced increases in MI, BC and reduced MP. Acetic acid induced urinary frequency as evidenced by a reduction in MI and was suppressed by CP55,940.

conclusionsCP55,940 decreases bladder activity and urinary frequency induced by nociceptive stimuli, probably by suppression of bladder afferent activity. Effects of CP55,940 were abolished by both CBR antagonists. This data implicates a role for the endocannabinoid system in bladder mechanoafferent function in rats. In addition, our results show that CP55,940 reverses urinary frequency exemplified in an overactive bladder model, suggesting it could be an effective treatment for patients with lower urinary tract symptoms.

Indexed as

Acetic AcidAdministration, IntravesicalAnimalsCannabinoid Receptor AgonistsCyclohexanolsDisease Models, AnimalFemaleIndolesPiperidinesPyrazolesRatsRats, Sprague-DawleyTreatment OutcomeUrinary BladderUrinary Bladder, OveractiveUrination3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolAcetic AcidAM 251Cannabinoid Receptor AgonistsCyclohexanolsIndolesiodopravadolinePiperidinesPyrazolesCannabinoid receptorsCystometryOveractive bladderUrinary bladder

Identifiers

PMID26942594
OpenAlexW2289483461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.