Evidence map›Paper›PMID 26942561›Full record

ArticleThe Angle orthodontist2016

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires.

Roberto Rongo, Rosa Valletta, Rosaria Bucci, Virginia Rivieccio, Angela Galeotti, Ambrosina Michelotti, Vincenzo D'Antò

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Angle orthodontist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Comparative evaluation of metal ion release and corrosion resistance of orthodontic archwires in different mouthwashes : From rinse to reactivity.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Roberto Rongoa  Research Fellow, School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II," Naples, Italy.
Rosa Vallettab  Associate Professor, School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II," Naples, Italy.
Rosaria Buccia  Research Fellow, School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II," Naples, Italy.
Virginia Rivieccioc  PhD, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II," Naples, Italy.
Angela Galeottid  Director of Division of Dentistry, Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy.
Ambrosina Michelottie  Professor and Chair, School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II," Naples, Italy.
Vincenzo D'Antòf  Research Fellow, School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II," Naples, Italy; and Division of Dentistry, Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the cytotoxicity of nickel-titanium (NiTi) esthetic orthodontic archwires with different surface coatings. MATERIALS AND

methodsThree fully coated, tooth-colored NiTi wires (BioCosmetic, Titanol Cosmetic, EverWhite), two ion-implanted wires (TMA Purple, Sentalloy High Aesthetic), five uncoated NiTi wires (BioStarter, BioTorque, Titanol Superelastic, Memory Wire Superelastic, and Sentalloy), one β-titanium wire (TMA), and one stainless steel wire (Stainless Steel) were considered for this study. The wire samples were placed at 37°C in airtight test tubes containing Dulbecco's Modified Eagle's Medium (0.1 mg/mL) for 1, 7, 14, and 30 days. The cell viability of human gingival fibroblasts (HGFs) cultured with this medium was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Data were analyzed by a two-way analysis of variance (α  =  .05).

resultsThe highest cytotoxic effect was reached on day 30 for all samples. The archwires exhibited a cytotoxicity on HGFs ranging from "none" to "slight," with the exception of the BioTorque, which resulted in moderate cytotoxicity on day 30. Significant differences were found between esthetic archwires and their uncoated pairs only for BioCosmetic (P  =  .001) and EverWhite (P < .001).

conclusionsUnder the experimental conditions, all of the NiTi esthetic archwires resulted in slight cytotoxicity, as did the respective uncoated wires. For this reason their clinical use may be considered to have similar risks to the uncoated archwires.

Indexed as

Esthetics, DentalNickelOrthodontic WiresTitaniumDental AlloysHumansMaterials TestingStainless SteelSurface PropertiesDental AlloysNickelStainless SteelTitaniumBiocompatibilityCoated wiresEsthetic archwiresOrthodontics

Identifiers

PMID26942561
PMCPMC8600826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.