ArticleIntensive care medicine2016
Extracorporeal membrane oxygenation: evolving epidemiology and mortality.
Article in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 10 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
191 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Efficacy of reduced-intensity or no heparin versus standard heparin anticoagulation in patients on extracorporeal membrane oxygenation: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Prognostic models for mortality risk in patients requiring ECMO.Intensive care medicine · 2023Pooled it
- Defining and understanding the "extra-corporeal membrane oxygenation gap" in the veno-venous configuration: Timing and causes of death.Artificial organs · 2022Pooled it
- [Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure : Short version of the S3 guideline].Der Anaesthesist · 2021Guideline
- [Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure : Short version of the S3 guideline].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Guideline
- Veno-Arterial Extracorporeal Life Support in Heart Transplant and Ventricle Assist Device Centres. Meta-analysis.ESC heart failure · 2021Pooled it
- Associations of therapeutic hypothermia with clinical outcomes in patients receiving ECPR after cardiac arrest: systematic review with meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Pooled it
- The impact of Centre's heart transplant status and volume on in-hospital outcomes following extracorporeal membrane oxygenation for refractory post-cardiotomy cardiogenic shock: a meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency.Deutsches Arzteblatt international · 2018Guideline
- Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis.Intensive care medicine · 2016Pooled it
- Population pharmacokinetics of remifentanil in critically ill patients receiving extracorporeal membrane oxygenation.Scientific reports · 2017Trial
- A Review of the Role of Artificial Intelligence in Patients on Extracorporeal Membrane Oxygenation: A Scoping Review Study.Health science reports · 2026Review
- Article
- Multimodal characterization of flow-induced thrombus initiation and growth in extracorporeal membrane oxygenation.Scientific reports · 2026Article
- Development of a nursing follow-up checklist for adult ECMO-treated discharged patients: a Delphi consensus and feasibility study.Frontiers in medicine · 2026Article
- Novel heat exchanger in extracorporeal circuit: technical and biological feasibility.Scientific reports · 2025Article
- Prognosis After Seven Days of Veno-Venous Extracorporeal Membrane Oxygenation Support.Artificial organs · 2025Article
- Retrospective cohort study of adult patients with cystic fibrosis supported with venovenous extracorporeal membrane oxygenation (VV ECMO) at a large German cystic fibrosis center.BMC pulmonary medicine · 2025Article
- Impact of different parameters on the outcome of vv-ECMO therapy in burn patients - a retrospective cohort study from a burn and high output ECMO center.Innovative surgical sciences · 2025Article
- [Quality assurance of extracorporeal membrane oxygenation (ECMO) - optimization through evidence-based quality indicators].Die Anaesthesiologie · 2025Review
131 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe evolution of the epidemiology and mortality of extracorporeal membrane oxygenation (ECMO) remains unclear. The present study investigates the evolving epidemiology and mortality of various ECMO techniques in Germany over time, used for both severe respiratory and cardiac failure.
methodsData on all patients receiving venovenous (vv-ECMO) and venoarterial (va-ECMO) ECMO as well as pumpless extracorporeal lung assist/interventional lung assist (PECLA/ILA) outside the operating room in Germany from 1 January 2007 through 31 December 2014 were obtained from the Federal Statistical Office of Germany and analyzed.
resultsThe incidence of vv-ECMO and va-ECMO in the population increased threefold from 1.0:100,000 inhabitants/year in 2007 to a maximum of 3.0:100,000 in 2012, and from 0.1:100,000 in 2007 to 0.7:100,000 in 2012 and to a maximum of 3.5:100,000 in 2014, respectively. The incidence of arteriovenous PECLA/ILA also increased from 0.4:100,000 to a maximum of 0.6:100,000 in 2011, but decreased thereafter to 0.3:100,000 in 2014. The relative proportion of older patients receiving ECMO is steadily increasing. In-hospital mortality decreased over time and reached 58 and 66 % for vv-ECMO and va-ECMO in 2014, respectively. In addition, mortality steadily increased with age and was especially high in the first 48 h of ECMO use.
conclusionsIn a high-income country like Germany, the use of ECMO has been rapidly increasing since 2007 for both respiratory and cardiac support, with a recent plateau in vv-ECMO use. In-hospital mortality decreased with increasing ECMO utilization, but remains high, especially in older patients and in the first 48 h of use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.