Trial reportBiological trace element research2016
Essential and Toxic Metals in Oral Fluid-a Potential Role in the Diagnosis of Periodontal Diseases.
Trial report in Biological trace element research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Macro and trace elements signature of periodontitis in saliva: A systematic review with quality assessment of ionomics studies.Journal of periodontal research · 2022Pooled it
- Investigating synovial trace elements as diagnostic markers in acute septic arthritis: an exploratory study.Clinical rheumatology · 2026Article
- Toward Smart Salivary Diagnostics: A Comprehensive Review of Heavy Metal Biomarkers and Digital Risk Modeling.Diagnostics (Basel, Switzerland) · 2026Review
- Ferroptosis and macrophage efferocytosis in periodontitis: Biological insights and therapeutic advances.Virulence · 2025Review
- Heavy Metals in Cannabis Vapes and Their Health Implications-A Scoping Review.TheScientificWorldJournal · 2025Article
- Copper Chelation Therapy Attenuates Periodontitis Inflammation through the Cuproptosis/Autophagy/Lysosome Axis.International journal of molecular sciences · 2024Article
- Association between systemic zinc and oxidative stress levels and periodontal inflamed surface area.Turkish journal of medical sciences · 2024Article
- A comprehensive analysis of the role of cuproptosis in periodontitis through integrated analysis of single-cell and bulk RNA sequencing.Archives of medical science : AMS · 2024Article
- Environmental tobacco smoke exposure is associated with increased levels of metals in children's saliva.Journal of exposure science & environmental epidemiology · 2023Article
- Heavy metals in drinking water and periodontitis: evidence from the national oral health survey from China.BMC public health · 2023Article
- Equine odontoclastic tooth resorption and hypercementosis (EOTRH): microspatial distribution of trace elements in hypercementosis-affected and unaffected hard dental tissues.Scientific reports · 2023Article
- Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements.Frontiers in veterinary science · 2023Article
- Zincon-Modified CNTs Electrochemical Tool for Salivary and Urinary Zinc Detection.Nanomaterials (Basel, Switzerland) · 2022Article
- Comparing Ionic Profile of Gingival Crevicular Fluid and Saliva as Distinctive Signature of Severe Periodontitis.Biomedicines · 2022Article
- Application of Copper Nanoparticles in Dentistry.Nanomaterials (Basel, Switzerland) · 2022Review
- Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections.Biophysical reviews · 2021Review
- Disease Ionomics: Understanding the Role of Ions in Complex Disease.International journal of molecular sciences · 2020Review
- ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis.Biomedicines · 2020Article
- Low levels of salivary metals, oral microbiome composition and dental decay.Scientific reports · 2020Article
- Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1BioMed research international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, many studies have investigated the relationship between the level of metals in the body and various diseases. The objective of this study was to examine any possible influence of periodontal disease upon the concentration of metals in oral fluid and blood and to explore the usability of applying cluster analysis coupled with the analysis of selected elements in oral fluid, calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), zinc (Zn), cadmium (Cd) and lead (Pb), for effectively distinguishing people affected by periodontitis from healthy individuals. The quantification of eight metals in oral fluid and blood samples was performed by two inductively coupled plasma techniques-inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). Most of the examined elements were detected at elevated concentration in the oral fluid of periodontal patients. However, the differences were statistically significant in the case of three metals: Cu, Mg and Mn (p < 0.05). Approximately, fivefold increase in the concentration of Cu, threefold-elevated levels of Mn and a twofold increase in the concentration of Mg were found in the oral fluid of the periodontal patients compared to the controls. Cluster analysis confirmed the statistical significance of the differences in the level of metals in the oral fluid between the two groups in most cases, plus enabled the correct classification of the subjects into patients and controls. The relationship between concentrations of metals and periodontal disease may in the future serve to prevent the development of such disease.
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