ArticleObstetrics and gynecology2016
Prophylactic Antibiotic Choice and Risk of Surgical Site Infection After Hysterectomy.
Article in Obstetrics and gynecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Risk factors for surgical site infection (SSI) in patients undergoing hysterectomy: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Antibiotic prophylaxis for elective hysterectomy.The Cochrane database of systematic reviews · 2017Pooled it
- Identifying potentially modifiable risk factors associated with racially disparate postoperative outcomes following benign hysterectomy.American journal of obstetrics and gynecology · 2026Article
- Risk factors for surgical site infections after hysterectomy: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Review
- Risk factors for surgical site infection following hysterectomy: nine-year experience at a large safety-net hospital network in New York City.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Symptomatic pelvic hematoma following hysterectomy: risk factors, bacterial pathogens and clinical outcome.BMC women's health · 2020Article
- Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.AJP reports · 2019Article
- Importance of Estimated Blood Loss in Resource Utilization and Complications of Hysterectomy for Benign Indications.Obstetrics and gynecology · 2019Article
- Surgical site infection reduction bundle in patients with gynecologic cancer undergoing colon surgery.Gynecologic oncology · 2017Article
- Predictive model of urinary tract infection after surgical treatment for women with endometrial cancer.Archives of gynecology and obstetrics · 2017Article
- Are perioperative bundles associated with reduced postoperative morbidity in women undergoing benign hysterectomy? Retrospective cohort analysis of 16,286 cases in Michigan.American journal of obstetrics and gynecology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate associations between prophylactic preoperative antibiotic choice and surgical site infection rates after hysterectomy.
methodsA retrospective cohort study was performed of patients in the Michigan Surgical Quality Collaborative undergoing hysterectomy from July 2012 to February 2015. The primary outcome was a composite outcome of any surgical site infection (superficial surgical site infections or combined deep organ space surgical site infections). Preoperative antibiotics were categorized based on the recommendations set forth by the American College of Obstetricians and Gynecologists and the Surgical Care Improvement Project. Patients receiving a recommended antibiotic regimen were categorized into those receiving β-lactam antibiotics and those receiving alternatives to β-lactam antibiotics. Patients receiving nonrecommended antibiotics were categorized into those receiving overtreatment (excluded from further analysis) and those receiving nonstandard antibiotics. Multivariable logistic regression models were developed to estimate the independent effect of antibiotic choice. Propensity score matching analysis was performed to validate the results.
resultsThe study included 21,358 hysterectomies. The overall rate of any surgical site infection was 2.06% (n=441). Unadjusted rates of "any surgical site infection" were 1.8%, 3.1%, and 3.7% for β-lactam, β-lactam alternatives, and nonstandard groups, respectively. After adjusting for patient and operative factors within clusters of hospitals, compared with the β-lactam antibiotics (reference group), the risk of "any surgical site infection" was higher for the group receiving β-lactam alternatives (odds ratio [OR] 1.7, confidence interval [CI] 1.27-2.07) or the nonstandard antibiotics (OR 2.0, CI 1.31-3.1).
conclusionCompared with women receiving β-lactam antibiotic regimens, there is a higher risk of surgical site infection after hysterectomy among those receiving a recommended β-lactam alternative or nonstandard regimen.
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