ArticleBioMed research international2016
Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- HIF1-α induces mitochondrial fission in trophoblastic cells during early pregnancy and in preeclampsia.iScience · 2026Article
- Mitochondrial Dysfunction Combined with Elevated CoQBiology · 2026Article
- The Role of Placental Mitochondrial Dysfunction in Adverse Perinatal Outcomes: A Systematic Review.Journal of clinical medicine · 2025Review
- A mitochondrial regulator protein, mitofusin 2, is elevated in the maternal blood of women with preeclampsia.BMC pregnancy and childbirth · 2025Article
- NADLife science alliance · 2024Article
- Pregnancy Disorders: A Potential Role for Mitochondrial Altered Homeostasis.Antioxidants (Basel, Switzerland) · 2024Review
- An integral role of mitochondrial function in the pathophysiology of preeclampsia.Molecular biology reports · 2024Review
- Quercetin stimulates trophoblast fusion via the mitochondrial function.Scientific reports · 2024Article
- Mitochondrial quality control alterations and placenta-related disorders.Frontiers in physiology · 2024Review
- Placental Mitochondrial Function and Dysfunction in Preeclampsia.International journal of molecular sciences · 2023Review
- Mitochondrial Dysfunction, Mitophagy and Their Correlation with Perinatal Complications: Preeclampsia and Low Birth Weight.Biomedicines · 2022Review
- Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia.Current hypertension reports · 2022Review
- Current Studies of Mitochondrial Quality Control in the Preeclampsia.Frontiers in cardiovascular medicine · 2022Review
- Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders.Molecular and cellular biochemistry · 2021Review
- Placental Mitochondrial Abnormalities in Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Mitochondrial fusion protein 2 regulates endoplasmic reticulum stress in preeclampsia.Journal of Zhejiang University. Science. B · 2021Article
- Article
- The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia.Genes & diseases · 2018Article
- Ceramide-induced BOK promotes mitochondrial fission in preeclampsia.Cell death & disease · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Mitofusin 2 (Mfn2) is a novel mitochondrial protein that is implicated in cellular proliferation and metabolism; however, the role of Mfn2 in preeclampsia (PE) remains unknown. This study aimed to explore the relationship between Mfn2 and PE. Method. Preeclamptic and normal pregnancies were enrolled in a comparative study. The expression of Mfn2 in placenta was detected by qRT-PCR. And the mitochondrial function was detected by ATP assay. Then TEV-1 cells were cultured in hypoxic conditions. mRNA and protein expressions of Mfn2 were detected by qRT-PCR and western blot separately. Cells' viability was detected by MTT. And the mitochondrial function was detected by ATP and mitochondrial membrane potential (MMP) assay. We further knocked down the Mfn2 gene in TEV-1 cells and evaluated the cells' viability. Results. Mfn2 and ATP expressions were significantly decreased in preeclamptic placentae compared to normal placentae. Mfn2 expression level and the viability of TEV-1 cells were reduced during hypoxic conditions. TEV-1 cells' viability, ATP, and MMP levels were also significantly decreased after knockdown of the Mfn2 gene. Conclusions. These results suggest that defects in Mfn2 could cause mitochondrial dysfunction and decrease trophoblastic cells' viability. Therefore, Mfn2 may be functionally involved in the pathogenesis of PE.
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