ReviewFrontiers in oncology2016
Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants.
Review in Frontiers in oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The role of mitochondria-associated membranes in tumorigenesis.Discover oncology · 2026Review
- The Pathophysiological Role of Mitochondria-associated Membranes in Coronary Artery Disease and Atherosclerosis.Current medicinal chemistry · 2026Review
- Changes inBiomedicines · 2024Article
- Li-Fraumeni Syndrome-Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death.Cancer discovery · 2023Article
- Mitochondrial Control of Genomic Instability in Cancer.Cancers · 2021Review
- Gain-of-function hot spot mutant p53Translational oncology · 2021Article
- Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology.Biomolecules · 2020Review
- Post-treatment with Posiphen Reduces Endoplasmic Reticulum Stress and Neurodegeneration in Stroke Brain.iScience · 2020Article
- miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the MouseFrontiers in cell and developmental biology · 2020Article
- Pifithrin-Alpha Reduces Methamphetamine Neurotoxicity in Cultured Dopaminergic Neurons.Neurotoxicity research · 2019Article
- Targeting a major hub of cell fate decisions - the mitochondrial-associated membrane.Haematologica · 2019Article
- Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during HOxidative medicine and cellular longevity · 2019Article
- Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.Neoplasia (New York, N.Y.) · 2018Review
- Emerging molecular mechanisms in chemotherapy: CaCell death & disease · 2018Review
- Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?Frontiers in oncology · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p53 protein is probably the most important tumor suppressor, acting as a nuclear transcription factor primarily through the modulation of cell death. However, currently, it is well accepted that p53 can also exert important transcription-independent pro-cell death actions. Indeed, cytosolic localization of endogenous wild-type or transactivation-deficient p53 is necessary and sufficient for the induction of apoptosis and autophagy. Here, we present the extra-nuclear activities of p53 associated with the mitochondria and the endoplasmic reticulum, highlighting the activities of the p53 mutants on these compartments. These two intracellular organelles play crucial roles in the regulation of cell death, and it is now well established that they also represent sites where p53 can accumulate.
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