ArticleNeuro-oncology practice2016
Understanding inherited genetic risk of adult glioma - a review.
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In one paragraph
Article in Neuro-oncology practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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0cells of the map it votes in
54citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Who cites it
54 citing papers in PubMed, 94 citations in OpenAlex.
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- Whole genome sequencing-based analysis of genetic predisposition to adult glioblastoma.NPJ genomic medicine · 2025Article
- Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses.JAMA oncology · 2025Article
- Key genes altered in glioblastoma based on bioinformatics (Review).Oncology letters · 2025Review
- Glioblastoma and Blood Microenvironment Predictive Model for Life Expectancy of Patients.Biomedicines · 2025Article
- Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies.Discover oncology · 2024Article
- FANCM Gene Variants in a Male Diagnosed with Sertoli Cell-Only Syndrome and Diffuse Astrocytoma.Genes · 2024Article
- Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.Scientific reports · 2024Article
- Machine learning-based investigation of regulated cell death for predicting prognosis and immunotherapy response in glioma patients.Scientific reports · 2024Article
- Integrated Gene Expression Data-Driven Identification of Molecular Signatures, Prognostic Biomarkers, and Drug Targets for Glioblastoma.BioMed research international · 2024Article
- Novel Therapies in Glioblastoma Treatment: Review of Glioblastoma; Current Treatment Options; and Novel Oncolytic Viral Therapies.Medical sciences (Basel, Switzerland) · 2023Review
- Recent Developments in Glioblastoma Therapy: Oncolytic Viruses and Emerging Future Strategies.Viruses · 2023Review
- Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations.Cancer biology & medicine · 2022Review
- Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment.eLife · 2022Article
- Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.Neuro-oncology practice · 2022Review
- Review
- Prospective investigation of herpesvirus infection and risk of glioma.International journal of cancer · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Terri RiceDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Daniel H LachanceDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Annette M MolinaroDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Jeanette E Eckel-PassowDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Kyle M WalshDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Jill Barnholtz-SloanDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Quinn T OstromDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Stephen S FrancisDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Joseph WiemelsDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Robert B JenkinsDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
John K WienckeDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Margaret R WrenschDivision of Neuroepidemiology, Department of Neurological Surgery , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (T.R., A.M.M., K.M.W, S.S.F., J.W., J.K.W., M.R.W.); Department of Laboratory Medicine and Pathology , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (D.H.L., R.B.J.); Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (D.H.L.) ; Department of Epidemiology and Biostatistics , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (A.M.M., J.W.); Division of Biomedical Statistics and Informatics , Mayo Clinic College of Medicine , 200 First Street SW, Rochester, MN 55905 (J.E.E.-P.); Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center , University of California , San Francisco, 1450 3rd Street, San Francisco, CA 94158 (K.M.W., J.W., J.K.W., M.R.W.); Case Comprehensive Cancer Center , Case Western Reserve University School of Medicine , 11100 Euclid Avenue, Cleveland, OH 44106-5065 (J.B.-S., Q.T.O.); Central Brain Tumor Registry of the United States , 244 East Ogden Ave Suite 116, Hinsdale, IL 60521 (J.B.-S., Q.T.O.).
Mayo Clinic · USNeurological Surgery · USUniversity of California, San Francisco · USCancer Genetics (United States) · USCase Western Reserve University · US
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3MUCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2MTissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4MTargeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5MGENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5MInternational Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0MTraining Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6MTraining in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5MBiomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5MNovel Tree-based Statistical Methods for Cancer Risk PredictionR01CA163687 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLINARO, ANNETTE M · 2012 to 2015
$1.3MIdentification of 9p and 20q Germline Alterations in Glioblastoma PathogenesisRC1NS068222 · NINDS · MAYO CLINIC ROCHESTER · PI JENKINS, ROBERT B. · 2009 to 2010
$984kNCCDPHP CDC HHS U58 DP003862NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA108961NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA126831NCI NIH HHS R01 CA139020NCI NIH HHS R01 CA163687NCI NIH HHS R25 CA112355NCI NIH HHS T32 CA151022NCRR NIH HHS UL1 RR024131NINDS NIH HHS RC1 NS068222
Abstract
During the past six years, researchers have made major progress identifying common inherited genetic variation that increases risk for primary adult glioma. This paper summarizes knowledge about rare familial cancer syndromes that include adult glioma and reviews the available literature on the more recently discovered common inherited variation. Ten independent inherited variants in eight chromosomal regions have been convincingly associated with increased risk for adult glioma. Most of these variants increase relative risk of primary adult glioma by 20% to 40%, but the TP53 variant rs78378222 confers a two-fold relative risk (ie, 200%), and rs557505857 on chromosome 8 confers a six-fold relative risk of
Indexed as
epidemiologygeneticsprimary adult gliomariskvariants
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