Evidence map›Paper›PMID 26941907›Full record

ArticleInternational journal of preventive medicine2016

The Protective Effect of γ-aminobutyric Acid on Kidney Injury Induced by Renal Ischemia-reperfusion in Ovariectomized Estradiol-treated Rats.

Nahid Talebi, Mehdi Nematbakhsh, Ramesh Monajemi, Safoora Mazaheri, Ardeshir Talebi, Marzieh Vafapour

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03482544 (Effect of Orally Pregabalin Given Before Knee Joint Replacement on Reperfusion Injury Which Caused by Bandage), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03482544 phase4completednot on this mapstarted 2018, after this paper: background citation

Effect of Orally Pregabalin Given Before Knee Joint Replacement on Reperfusion Injury Which Caused by Bandage

TypeinterventionalSponsorBaskent UniversityRan2018 to 2018Enrolled54ConditionsIschemia Reperfusion InjuryArmsPragabalin, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Nephroprotective effect of methanol extract ofAfrican health sciences · 2020
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nahid TalebiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Mehdi NematbakhshWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Institute of Basic and Applied Sciences Research, Isfahan, Iran.
Ramesh MonajemiDepartment of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Safoora MazaheriWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ardeshir TalebiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
Marzieh VafapourWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Isfahan University of Medical Sciences · IRIslamic Azad University, Isfahan · IRIslamic Azad University of Falavarjan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRenal ischemia-reperfusion injury (IRI) is one of the most important causes of kidney injury, which is possibly gender-related. This study was designed to investigate the role of γ-aminobutyric acid (GABA) against IRI in ovariectomized estradiol-treated rats.

methodsThirty-five ovariectomized Wistar rats were used in six experimental groups. The first three groups did not subject to estradiol treatment and assigned as sham-operated, control, and GABA-treated groups. GABA (50 μmol/kg) and saline were injected in the treated and control groups 30 min before the surgery, respectively. The second three groups received the same treatments but received estradiol valerate (500 μg/kg, intramuscularly) 3 days prior to the surgery. The IRI was induced in the control and treated groups by clamping the renal artery for 45 min and then 24 h of reperfusion. All animals were sacrificed for the measurements.

resultsThe serum levels of creatinine and blood urea nitrogen, kidney weight, and kidney tissue damage score significantly increased in the IRI rats (P < 0.05). GABA significantly decreased the aforementioned parameters (P < 0.05). The uterus weight increased significantly in rats that received estradiol (P < 0.05). Serum and kidney levels of nitrite (nitric oxide metabolite) did not alter significantly. Serum level of malondialdehyde increased significantly in the ovariectomized rats exposed to IRI (P < 0.05).

conclusionsIt seems that GABA improved IRI in ovariectomized rats. Estradiol was also nephroprotective against IRI. However, co-administration of estradiol and GABA could not protect the kidney against IRI.

Indexed as

Estradiolovariectomized ratsrenal ischemia-reperfusionγ-aminobutyric acid

Identifiers

PMID26941907
PMCPMC4755213
OpenAlexW2288274228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.