Evidence map›Paper›PMID 26941575›Full record

ArticleInternational journal of medical sciences2016

Functional Role of FcγRIIB in the Regulation of Mesenchymal Stem Cell Function.

Tianyi Zhu, Ruohua Chen, Zeng Li, Jun Tian, Changwen Deng, Xingxing Zhang, Koudong Zhang, Linrong Tong, Yizhi Yu, Chong Bai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Tianyi Zhu1. Department of Respiratory, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;; 2. Department of Respiratory, The General Hospital of Shenyang Military, Shenyang, Liaoning, 110015, China;
Ruohua Chen3. Department of VIP Treatment, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
Zeng Li4. Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, China;
Jun Tian5. Department of Immunology, Zhejiang University, Hangzhou, Zhejiang310000, China;
Changwen Deng1. Department of Respiratory, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
Xingxing Zhang1. Department of Respiratory, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
Koudong Zhang6. Department of Respiratory, No. 1 People's Hospital of Yancheng, Yancheng, Jiangsu, 224000, China;
Linrong Tong7. Department of Respiratory, The 174 Hospital, Xiamen, Fujian, 361000, China.
Yizhi Yu8. Institute of Immunology, The Second Military Medical University, Shanghai, 200433, China.
Chong Bai1. Department of Respiratory, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
Changhai Hospital · CNSecond Military Medical University · CN174th hospital of the People's Liberation Army · CNJiangsu Province Hospital · CNNantong University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) derived from bone marrow are plural-potent stem cells with immune regulatory functions. We aimed to evaluate role of FcγRIIB in the regulation of bone marrow-derived MSC function. MSCs were prepared from mouse bone marrow derived from wild-type (WT) or FcγRIIB-deficient (FcγRIIB-/-) mice. MSCs were co-cultured with bone marrow-derived dendritic cells (BMDCs), and BMDC maturation and function were evaluated by flow cytometric analysis and carboxyfluorescein succinimidyl ester-labeled OT-II T-cell addition. An acute asthma model was established by aeresol ovalbumin challenge in mice. Mice received WT or FcγRIIB-/- MSC therapy. Lung function was evaluated by histological examination and cytokine production measurement. mRNA and protein expression levels of target genes were examined by real-time quantitative polymerase chain reactionor western blotting. We found that MSCs derived from bone marrow exhibit a high level of FcγRIIB expression. FcγRIIB deficiency impaired the suppressive function of MSCs, as FcγRIIB deficiency efficiently reversed the inhibitory effect of MSCs on BMDC maturation and function. Additionally, FcγRIIB-/-MSCs were less potent at suppressing asthma in model mice, possibly through reduced expression of Smad2, Smad3, Cox-2, and prostaglandin E2 in FcγRIIB-/-MSCs. FcγRIIB might play an essential role in regulating the inhibitory effects of MSCs derived from bone marrow.

Indexed as

AnimalsAsthmaCells, CulturedCoculture TechniquesCyclooxygenase 2Dendritic CellsDinoprostoneDisease Models, AnimalMesenchymal Stem CellsMice, Inbred BALB CMice, KnockoutReceptors, IgGSmad2 ProteinSmad3 ProteinT-LymphocytesCyclooxygenase 2DinoprostoneFcgr2b protein, mousePtgs2 protein, mouseReceptors, IgGSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseasthma.dendritic cell maturationFcγRIIBmesenchymal stem cells

Identifiers

PMID26941575
PMCPMC4764783
OpenAlexW2337908032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.