ArticleJournal of statistical physics
Know the Single-Receptor Sensing Limit? Think Again.
Article in Journal of statistical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Article
- Fundamental limits on nonequilibrium sensing.Nature communications · 2025Article
- ChemotaxingArXiv · 2025Article
- ChemotaxingbioRxiv : the preprint server for biology · 2025Article
- Learning optimal integration of spatial and temporal information in noisy chemotaxis.PNAS nexus · 2024Article
- Single-cell directional sensing from just a few receptor binding events.Biophysical journal · 2023Article
- Size limits the sensitivity of kinetic schemes.Nature communications · 2023Article
- Revising Berg-Purcell for finite receptor kinetics.Biophysical journal · 2021Article
- A mechanism foreLife · 2020Article
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- Mixed analytical-stochastic simulation method for the recovery of a Brownian gradient source from probability fluxes to small windows.Journal of computational physics · 2018Article
- Reconstructing the gradient source position from steady-state fluxes to small receptors.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How cells reliably infer information about their environment is a fundamentally important question. While sensing and signaling generally start with cell-surface receptors, the degree of accuracy with which a cell can measure external ligand concentration with even the simplest device-a single receptor-is surprisingly hard to pin down. Recent studies provide conflicting results for the fundamental physical limits. Comparison is made difficult as different studies either suggest different readout mechanisms of the ligand-receptor occupancy, or differ on how ligand diffusion is implemented. Here we critically analyse these studies and present a unifying perspective on the limits of sensing, with wide-ranging biological implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.