ArticleCerebral cortex (New York, N.Y. : 1991)2017
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Emerging Role of Tripartite Synaptic Transmission in the Pathomechanism of Autosomal-Dominant Sleep-Related Hypermotor Epilepsy.International journal of molecular sciences · 2025Review
- Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures.Neurology · 2025Article
- Lateral septal inhibition of nucleus basalis through direct and indirect pathways in focal limbic seizures.bioRxiv : the preprint server for biology · 2025Article
- Decreased locus coeruleus multiunit activity in a mouse model of temporal lobe seizures with impaired consciousness.Experimental neurology · 2025Article
- Subcortical Circuits Among Pedunculopontine Nucleus, Thalamus and Basal Ganglia Play Important Roles in Paroxysmal Arousal in Genetic Rat Models of Autosomal Dominant Sleep-Related Hypermotor Epilepsy.International journal of molecular sciences · 2025Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.NeuroImage · 2025Article
- Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness.Cell reports · 2024Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.bioRxiv : the preprint server for biology · 2024Article
- [Current progress on characteristics of intracranial electrophysiology related to prolonged disorders of consciousness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Article
- Review
- Progressive generalized tonic-clonic seizures in a transgenic mouse model of adult-onset epilepsy: Implications for morphological changes in cortico-limbic and brainstem structures.Epilepsy research · 2023Article
- Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.Brain : a journal of neurology · 2023Article
- Structural connections of the centromedian nucleus of thalamus and their relevance for neuromodulation in generalized drug-resistant epilepsy: insight from a tractography study.Therapeutic advances in neurological disorders · 2023Article
- Editorial: All roads lead to Rome: Harnessing thalamic neuromodulation for difficult-to-treat neurological disorders.Frontiers in human neuroscience · 2023Article
- Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022Review
- Distinct Fastigial Output Channels and Their Impact on Temporal Lobe Seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Impaired consciousness occurs suddenly and unpredictably in people with epilepsy, markedly worsening quality of life and increasing risk of mortality. Focal seizures with impaired consciousness are the most common form of epilepsy and are refractory to all current medical and surgical therapies in about one-sixth of cases. Restoring consciousness during and following seizures would be potentially transformative for these individuals. Here, we investigate deep brain stimulation to improve level of conscious arousal in a rat model of focal limbic seizures. We found that dual-site stimulation of the central lateral nucleus of the intralaminar thalamus (CL) and the pontine nucleus oralis (PnO) bilaterally during focal limbic seizures restored normal-appearing cortical electrophysiology and markedly improved behavioral arousal. In contrast, single-site bilateral stimulation of CL or PnO alone was insufficient to achieve the same result. These findings support the "network inhibition hypothesis" that focal limbic seizures impair consciousness through widespread inhibition of subcortical arousal. Driving subcortical arousal function would be a novel therapeutic approach to some forms of refractory epilepsy and may be compatible with devices already in use for responsive neurostimulation. Multisite deep brain stimulation of subcortical arousal structures may benefit not only patients with epilepsy but also those with other disorders of consciousness.
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Registered trials
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