SynthesisMolecular neurobiology2017
The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis.
Synthesis in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Impact of SNAP-25 MnlI polymorphism on brain activity patterns in children with ADHD: Insights from fractional amplitude of low-frequency fluctuation analysis.Neuroimage. Reports · 2026Article
- Transcriptomic Dysregulation in Animal Models of Attention-Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms.Brain and behavior · 2025Article
- Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8British journal of cancer · 2024Article
- A systematic meta-review of systematic reviews on attention deficit hyperactivity disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2023Review
- The Role ofInternational journal of molecular sciences · 2023Article
- Polymorphism of Estrogen Receptor Genes and Its Interactions With Neurodevelopmental Genes in Attention Deficit Hyperactivity Disorder Among Chinese Han Descent.Psychiatry investigation · 2023Article
- Using fNIRS to evaluate ADHD medication effects on neuronal activity: A systematic literature review.Frontiers in neuroimaging · 2023Article
- miR-23a-3p and miR-181a-5p modulate SNAP-25 expression.PloS one · 2023Article
- Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review.Journal of personalized medicine · 2022Review
- Role of SNAP-25 MnlI variant in impaired working memory and brain functions in attention deficit/hyperactivity disorder.Brain and behavior · 2022Article
- Animal Models of ADHD?Current topics in behavioral neurosciences · 2022Article
- The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.Neuroscience and biobehavioral reviews · 2021Review
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- Molecular Evolution and Characterization of Fish Stathmin Genes.Animals : an open access journal from MDPI · 2020Article
- Detection of epistasis between ACTN3 and SNAP-25 with an insight towards gymnastic aptitude identification.PloS one · 2020Article
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- A Multilevel Functional Study of aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Relationship between theClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells.Frontiers in molecular neuroscience · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attention deficit/hyperactivity disorder (ADHD) is one of the most highly heritable psychiatric disorders in childhood. The risk gene mutation accounts for about 60 to 90 % cases. Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic plasma membrane protein which is expressed highly and specifically in the neuronal cells. A number of evidences have suggested the role of SNAP-25 in the etiology of ADHD. Notably, the animal model of coloboma mouse mutant bears a ∼2-cM deletion encompassing genes including SNAP25 and displays spontaneous hyperkinetic behavior. Previous investigators have reported association between SNPs in SNAP25 and ADHD, and controversial results were observed. In this study, we analyzed the possible association between six polymorphisms (rs3746544, rs363006, rs1051312, rs8636, rs362549, and rs362998) of SNAP25 and ADHD in a pooled sample of ten family-based studies and four case-control studies by using meta-analysis. The combined analysis results were significant only for rs3746544 (P = 0.010) with mild association (odds ratio (OR) = 1.14). And, the meta-analysis data for rs8636, rs362549, and rs362998 are the first time to be reported; however, no positive association was detected. In conclusion, we report some evidence supporting the association of SNAP25 to ADHD. Future research should emphasize genome-wide association studies in more specific subgroups and larger independent samples.
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