ArticleJournal of assisted reproduction and genetics2016
Diagnostic application of total antioxidant capacity in seminal plasma to assess oxidative stress in male factor infertility.
Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reproductive health needs of HIV serodiscordant couples: a systematic review.Frontiers in public health · 2024Pooled it
- Protective effects of coenzyme Q10-supplemented cryopreservation medium on oxidative stress in frozen canine sperm.Veterinary research communications · 2026Article
- Oxidative Stress, Sperm DNA Fragmentation, or Both? Optimizing Test Selection in Male Infertility Evaluation.Antioxidants (Basel, Switzerland) · 2026Review
- From fork to fatherhood: Unveiling the link between dietary pattern indices and biochemical parameters of semen.PloS one · 2026Article
- Impact of Short-Term Abstinence on Semen Quality and Oxidative Stress in Men with Suboptimal Semen Parameters: A Prospective Observational Study at a Tertiary IVF Centre.JBRA assisted reproduction · 2026Observational
- Influence of Body Mass Index (BMI) and Waist-Hip Ratio (WHR) on Selected Semen Parameters.International journal of molecular sciences · 2025Article
- Oxidative Stress-induced Hormonal Disruption in Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Serological and histolomorphological investigation of camel bulls testes (Camelus dromedaries) during the rutting and non-rutting seasons.BMC veterinary research · 2024Article
- Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- The role of seminal reactive oxygen species assessment in the setting of infertility and early pregnancy loss.World journal of urology · 2023Article
- Blood Leukocyte ROS Production Reflects Seminal Fluid Oxidative Stress and Spermatozoa Dysfunction in Idiopathic Infertile Men.Antioxidants (Basel, Switzerland) · 2023Article
- Sperm cryopreservation for impaired spermatogenesis.Reproduction & fertility · 2023Article
- Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight.Frontiers in endocrinology · 2023Review
- Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects.International journal of molecular sciences · 2022Review
- The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress.International journal of environmental research and public health · 2022Article
- Mitochondrial metabolism determines the functional status of human sperm and correlates with semen parameters.Frontiers in cell and developmental biology · 2022Article
- Oxidative profile and protease regulator potential to predict sperm functionality in donkey (Equus asinus).Scientific reports · 2021Article
- Oxidative stress and DNA damage status in couples undergoingReproduction & fertility · 2021Article
- Influence of Fruit and Vegetable Consumption on Antioxidant Status and Semen Quality: A Cross-Sectional Study in Adult Men.Frontiers in nutrition · 2021Article
- The Impact of Oxidative Stress in Male Infertility.Frontiers in molecular biosciences · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
purposeThis study was undertaken in order to establish a new reference value for the total antioxidant capacity (TAC) in seminal plasma as a predictor of fertility. This study also aims to propose a detailed protocol for the TAC assay including calculation of assay results and assessment of sensitivity and specificity over possible cutoff values in infertile men and controls with proven and unproven fertility.
methodsSeminal plasma from 279 infertile patients and 46 normal healthy men referred to a male infertility testing laboratory were tested to measure TAC by a colorimetric assay kit. Receiver operating characteristics (ROC) curves were generated to establish cutoff values, sensitivity, and specificity, and the distribution of cutoff values in controls and infertile patients was calculated.
resultsInfertile patients showed significantly lower levels (mean ± SEM) of total antioxidants (micromolar Trolox equivalents) in their seminal plasma (1863.84 ± 27.16 μM) compared to those from fertile men (2013 ± 56.04 μM, P = 0.019). A preferred cutoff TAC value of 1947 μM could facilitate better diagnosis of oxidative stress (OS) in men with male factor infertility. At this threshold, the specificity of TAC assay was 63.0 % and the sensitivity 59.5 % with a positive predictive value of 90.7 % and a negative predictive value of 20.4 %.
conclusionsOur results establish a new diagnostic cutoff TAC value of 1947 μM in seminal plasma to distinguish prevalence of OS in infertile patients compared to healthy men. This study provides a robust reference value of seminal plasma TAC that may provide an important diagnostic tool to the physicians for managing OS and male factor infertility in such patients.
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