ArticleThe Plant cell2016
A Geranylfarnesyl Diphosphate Synthase Provides the Precursor for Sesterterpenoid (C25) Formation in the Glandular Trichomes of the Mint Species Leucosceptrum canum.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 63 citations in OpenAlex.
- Integrated characterization of six sesquiterpene synthases unravels diversified terpene biosynthesis in the mint speciesFrontiers in plant science · 2026Article
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- From Monocyclization to Pentacyclization: A Versatile Plant Cyclase Produces Diverse Sesterterpenes with Anti-Liver Fibrosis Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Systematic characterization and functional analysis ofFrontiers in plant science · 2025Article
- Qualitative Profiling, Antioxidant and Antimicrobial Activities of Polar and Nonpolar Basil Extracts.Foods (Basel, Switzerland) · 2024Article
- The Chemical Ecology of Plant Natural Products.Progress in the chemistry of organic natural products · 2024Review
- The functional evolution of architecturally different plant geranyl diphosphate synthases from geranylgeranyl diphosphate synthase.The Plant cell · 2023Article
- Essential Oils and Their Compounds as Potential Anti-Influenza Agents.Molecules (Basel, Switzerland) · 2022Review
- Functional Prediction ofInternational journal of molecular sciences · 2022Article
- Transcriptomic and metabolomic analysis reveals the difference between large and small flower taxa of Herba Epimedii during flavonoid accumulation.Scientific reports · 2022Article
- Investigation of the Anti-Inflammatory Activity of Fusaproliferin Analogues Guided by Transcriptome Analysis.Frontiers in pharmacology · 2022Article
- Effects of 5-azaC on Iridoid Glycoside Accumulation and DNA Methylation inFrontiers in plant science · 2022Article
- An extremely promiscuous terpenoid synthase from the Lamiaceae plantPlant communications · 2021Article
- Occurrence and biosynthesis of plant sesterterpenes (C25), a new addition to terpene diversity.Plant communications · 2021Review
- Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases.Plant communications · 2020Article
- Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species.BMC plant biology · 2020Article
- Combined Metabolome and Transcriptome Analyses Reveal the Effects of Mycorrhizal FungusInternational journal of molecular sciences · 2020Article
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13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant sesterterpenoids, an important class of terpenoids, are widely distributed in various plants, including food crops. However, little is known about their biosynthesis. Here, we cloned and functionally characterized a plant geranylfarnesyl diphosphate synthase (Lc-GFDPS), the enzyme producing the C25 prenyl diphosphate precursor to all sesterterpenoids, from the glandular trichomes of the woody plant Leucosceptrum canum. GFDPS catalyzed the formation of GFDP after expression in Escherichia coli. Overexpressing GFDPS in Arabidopsis thaliana also gave an extract catalyzing GFDP formation. GFDPS was strongly expressed in glandular trichomes, and its transcript profile was completely in accordance with the sesterterpenoid accumulation pattern. GFDPS is localized to the plastids, and inhibitor studies indicated its use of isoprenyl diphosphate substrates supplied by the 2-C-methyl-D-erythritol 4-phosphate pathway. Application of a jasmonate defense hormone induced GFDPS transcript and sesterterpenoid accumulation, while reducing feeding and growth of the generalist insect Spodoptera exigua, suggesting that these C25 terpenoids play a defensive role. Phylogenetic analysis suggested that GFDPS probably evolved from plant geranylgeranyl diphosphate synthase under the influence of positive selection. The isolation of GFDPS provides a model for investigating sesterterpenoid formation in other species and a tool for manipulating the formation of this group in plants and other organisms.
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