ArticleJournal of molecular neuroscience : MN2016
Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis.
Article in Journal of molecular neuroscience : MN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- A New Gal in Town: A Systematic Review of the Role of Galanin and Its Receptors in Experimental Pain.Cells · 2022Pooled it
- Dual Targeting of Galanin Receptor 3 Signaling and Redox Homeostasis Enhances Photoreceptor Survival in Retinas ofAntioxidants (Basel, Switzerland) · 2026Article
- Immunohistochemical characterization of nerve fibers supplying canine elbow joint capsule.BMC veterinary research · 2026Article
- Inhibition of galanin receptor 3 slows down retina degeneration in retinitis pigmentosa through modulation of inflammatory and oxidative stress response.Scientific reports · 2026Article
- Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Article
- Galanin receptor 3 - A new pharmacological target in retina degeneration.Pharmacological research · 2023Article
- Distribution and possible function of galanin about headache and immune system in the rat dura mater.Scientific reports · 2022Article
- Neuroimmunomodulation by gut bacteria: Focus on inflammatory bowel diseases.World journal of gastrointestinal pathophysiology · 2021Review
- Capsaicin-Sensitive Peptidergic Sensory Nerves Are Anti-Inflammatory Gatekeepers in the Hyperacute Phase of a Mouse Rheumatoid Arthritis Model.International journal of molecular sciences · 2021Article
- Protective Role of Galanin during Chemically Induced Inflammation in Zebrafish Larvae.Biology · 2021Article
- Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model.Scientific reports · 2021Article
- Repetitive in vivo manual loading of the spine elicits cellular responses in porcine annuli fibrosi.PloS one · 2021Article
- Galanin System in Human Glioma and Pituitary Adenoma.Frontiers in endocrinology · 2020Article
- Influence of the regulatory peptide galanin on cytokine expression in human monocytes.Annals of the New York Academy of Sciences · 2019Article
- Galanin is a potent modulator of cytokine and chemokine expression in human macrophages.Scientific reports · 2019Article
- Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.Journal of neuroinflammation · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Neurogenic inflammation mediated by peptidergic sensory nerves has a crucial impact on the pathogenesis of various joint diseases. Galanin is a regulatory sensory neuropeptide, which has been shown to attenuate neurogenic inflammation, modulate neutrophil activation, and be involved in the development of adjuvant arthritis, but our current understanding about its targets and physiological importance is incomplete. Among the receptors of galanin (GAL1-3), GAL3 has been found to be the most abundantly expressed in the vasculature and on the surface of some immune cells. However, since there are minimal in vivo data on the role of GAL3 in joint diseases, we analyzed its involvement in different inflammatory mechanisms of the K/BxN serum transfer-model of autoimmune arthritis employing GAL 3 gene-deficient mice. After arthritis induction, GAL3 knockouts demonstrated increased clinical disease severity and earlier hindlimb edema than wild types. Vascular hyperpermeability determined by in vivo fluorescence imaging was also elevated compared to the wild-type controls. However, neutrophil accumulation detected by in vivo luminescence imaging or arthritic mechanical hyperalgesia was not altered by the lack of the GAL3 receptor. Our findings suggest that GAL3 has anti-inflammatory properties in joints by inhibiting vascular hyperpermeability and consequent edema formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.