ArticleNature communications2016
A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Coral growth, retraction, defense, and regenerative strategies revealed by live microCT.Science advances · 2026Article
- Studying Microplastic Incorporation into Corals Using CARS.Environmental science & technology · 2026Article
- Brine Shrimp Feeding Contributes to Fast Growth and Enhanced Immune Capacity of Reattached Polyps of Scleractinian CoralAnimals : an open access journal from MDPI · 2025Article
- Acousto-optogenetics bandpass stabilizer: A programmable platform for mapping single-cell phenotypic life trajectories.Materials today. Bio · 2025Article
- Saving coral reefs: significance and biotechnological approaches for coral conservation.Advanced biotechnology · 2024Review
- Non-invasive investigation of the morphology and optical properties of the upside-down jellyfishProceedings. Biological sciences · 2023Article
- iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays.Nature communications · 2023Article
- Bacterial Community Shifts during Polyp Bail-Out Induction inMicrobiology spectrum · 2023Article
- Coral holobiont research needs spatial analyses at the microbial scale.Environmental microbiology · 2023Article
- Harnessing the Power of Model Organisms To Unravel Microbial Functions in the Coral Holobiont.Microbiology and molecular biology reviews : MMBR · 2022Review
- The coral pathogen Vibrio coralliilyticus kills non-pathogenic holobiont competitors by triggering prophage induction.Nature ecology & evolution · 2022Article
- Article
- Genetic changes involving the coral gastrovascular system support the transition between colonies and bailed-out polyps: evidence from a Pocillopora acuta transcriptome.BMC genomics · 2021Article
- Enhancement of microalgae growth using magnetic artificial cilia.Biotechnology and bioengineering · 2021Article
- The history, biological relevance, and potential applications for polyp bailout in corals.Ecology and evolution · 2021Review
- Microscale tracking of coral-vibrio interactions.ISME communications · 2021Article
- Luminescence lifetime imaging of three-dimensional biological objects.Journal of cell science · 2021Article
- Active carpets drive non-equilibrium diffusion and enhanced molecular fluxes.Nature communications · 2021Article
- Crystal nucleation and growth of spherulites demonstrated by coral skeletons and phase-field simulations.Acta biomaterialia · 2021Article
- Applying model approaches in non-model systems: A review and case study on coral cell culture.PloS one · 2021Review
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coral reefs, and the unique ecosystems they support, are facing severe threats by human activities and climate change. Our understanding of these threats is hampered by the lack of robust approaches for studying the micro-scale interactions between corals and their environment. Here we present an experimental platform, coral-on-a-chip, combining micropropagation and microfluidics to allow direct microscopic study of live coral polyps. The small and transparent coral micropropagates are ideally suited for live-imaging microscopy, while the microfluidic platform facilitates long-term visualization under controlled environmental conditions. We demonstrate the usefulness of this approach by imaging coral micropropagates at previously unattainable spatio-temporal resolutions, providing new insights into several micro-scale processes including coral calcification, coral-pathogen interaction and the loss of algal symbionts (coral bleaching). Coral-on-a-chip thus provides a powerful method for studying coral physiology in vivo at the micro-scale, opening new vistas in coral biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.