ReviewJournal of the American College of Cardiology2016
Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".
Review in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
176 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study.European heart journal. Cardiovascular pharmacotherapy · 2025Pooled it
- The association between anti-inflammatory therapies and renal outcomes in patients with established cardiovascular disease or high cardiovascular risks: a meta-analysis of randomised controlled trials.Inflammopharmacology · 2025Pooled it
- Cardiovascular autonomic effects of electronic cigarette use: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Pooled it
- Social Support and Antibody Responses to Vaccination: A Meta-Analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Pooled it
- Cardiac manifestations in COVID-19 patients-A systematic review.Journal of cardiac surgery · 2020Pooled it
- Detection of Atherosclerotic Inflammation byJournal of the American College of Cardiology · 2017 · on this mapTrial
- Pain mediates the association between psychological distress and increases in inflammation in middle-aged and older rural adults: A longitudinal cohort study.Brain, behavior, & immunity - health · 2026Article
- Nationwide cohort analysis of pediatric urolithiasis: long-term metabolic, renal, and cardiovascular outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Subclinical coronary artery calcification is associated with future inflammatory conditions in the multi-ethnic study of atherosclerosis.American journal of preventive cardiology · 2026Article
- Plaque Progression and Rupture in Obstructive Coronary Artery Disease: A Review of Current Imaging Modalities.Reviews in cardiovascular medicine · 2026Review
- Article
- Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms.Journal of clinical medicine · 2026Review
- A nomogram for predicting intraoperative risk during primary percutaneous coronary intervention based on rapidly obtained data from ST-segment elevation myocardial infarction patients.Frontiers in cardiovascular medicine · 2026Article
- Heart-brain axis pathophysiological understanding and clinical impact.Frontiers in cardiovascular medicine · 2026Review
- Cardiac Autonomic Dysfunction and Increased Oxidative Stress in Conventional Cigarettes and E-Cigarettes: Heart Rate Variability as a Cardiovascular Predictor.Antioxidants (Basel, Switzerland) · 2025Review
- Exploring the bidirectional relationships between MRI resting-state functional connectivity networks and cardiovascular diseases: a Mendelian randomization study.Brain informatics · 2025Article
- Renal denervation attenuates cardiac inflammatory responses via the afferent renal-splenic nerve axis after myocardial ischemic injury.Journal of translational medicine · 2025Article
- Inflammatory Biomarkers in Heart Failure: Clinical Perspectives on hsCRP, IL-6 and Emerging Candidates.Current heart failure reports · 2025Review
- Shared Mechanisms in Cancer and Cardiovascular Disease: S100A8/9 and the NLRP3 Inflammasome: JACC: CardioOncology State-of-the-Art Review.JACC. CardioOncology · 2025Review
- Plasmapheresis as a Potential Generalizable Therapy for Myocardial Infarction.Rejuvenation research · 2025Review
116 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner: plaques grow in arteries until they block blood flow, causing acute coronary and other ischemic syndromes. Recent research provides new insight into the integrative biology of inflammation as it contributes to ischemic cardiovascular disease. These results have revealed hitherto unsuspected inflammatory signaling networks at work in these disorders that link the brain, autonomic nervous system, bone marrow, and spleen to the atherosclerotic plaque and to the infarcting myocardium. A burgeoning clinical published data indicates that such inflammatory networks-far from a mere laboratory curiosity-operate in our patients and can influence aspects of ischemic cardiovascular disease that determine decisively clinical outcomes. These new findings enlarge the circle of the traditional "cardiovascular continuum" beyond the heart and vessels to include the nervous system, the spleen, and the bone marrow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.