Evidence map›Paper›PMID 26940762›Full record

ArticleScientific reports2016

An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles.

Nicole M Smith, Ivana Gachulincova, Diwei Ho, Charlotte Bailey, Carole A Bartlett, Marck Norret, John Murphy, Alysia Buckley, Paul J Rigby, Michael J House and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  11. Development of Novel Therapeutics Targeting the Blood-Brain Barrier: From Barrier to Carrier.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Potential Application of Upconverting Nanoparticles for Brain Photobiomodulation.Photobiomodulation, photomedicine, and laser surgery · 2019
    Review
  16. Article
  17. Gene Therapy for Human Sensorineural Hearing Loss.Frontiers in cellular neuroscience · 2019
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Nicole M SmithExperimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Ivana GachulincovaExperimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Diwei HoSchool of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
Charlotte BaileyExperimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Carole A BartlettExperimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Marck NorretSchool of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
John MurphyCentre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
Alysia BuckleyCentre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
Paul J RigbyCentre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
Michael J HouseSchool of Physics, The University of Western Australia, Perth, WA 6009, Australia.
Timothy St PierreSchool of Physics, The University of Western Australia, Perth, WA 6009, Australia.
Melinda FitzgeraldExperimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
K Swaminathan IyerSchool of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
Sarah A DunlopExperimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable.

Indexed as

Optic Nerve InjuriesAdministration, IntravenousAnimalsBiological TransportBlood-Brain BarrierBrain DiseasesDisease Models, AnimalFemaleHumansNanoparticlesOptic NervePolymersRatsRats, Inbred StrainsTissue DistributionPolymers

Identifiers

PMID26940762
PMCPMC4778073
OpenAlexW2315982547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.