ArticleScientific reports2016
HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evolutionary pathway and genetic mechanisms of fin-to-limb transition in vertebrates.Frontiers in cell and developmental biology · 2026Review
- Article
- The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark Scyliorhinus Canicula Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates.Molecular biology and evolution · 2024Article
- Anterior-posterior constraint on Hedgehog signaling by hhip in teleost fin elaboration.Development (Cambridge, England) · 2024Article
- Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals.Proceedings. Biological sciences · 2024Article
- The Chromosome-Scale Genome ofBiology · 2024Article
- The Development of theJournal of developmental biology · 2022Article
- Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.Nature communications · 2021Article
- Future Tail Tales: A Forward-Looking, Integrative Perspective on Tail Research.Integrative and comparative biology · 2021Review
- The bowfin genome illuminates the developmental evolution of ray-finned fishes.Nature genetics · 2021Article
- Sarcopterygian fin ontogeny elucidates the origin of hands with digits.Science advances · 2020Article
- Developmental constraints on fin diversity.Development, growth & differentiation · 2020Review
- A dot-stripe Turing model of joint patterning in the tetrapod limb.Development (Cambridge, England) · 2020Article
- Pattern of fin rays along the antero-posterior axis based on their connection to distal radials.Zoological letters · 2019Article
- Expression ofEvoDevo · 2018Article
- Problems in Fish-to-Tetrapod Transition: Genetic Expeditions Into Old Specimens.Frontiers in cell and developmental biology · 2018Review
- Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod.Proceedings. Biological sciences · 2017Article
- Article
- Deep phylogenomics of a tandem-repeat galectin regulating appendicular skeletal pattern formation.BMC evolutionary biology · 2016Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of HoxD genes, as well as the cluster-associated genes Evx2 and LNP, in the paddlefish Polyodon spathula, a basal ray-finned fish. Our results demonstrate a collinear pattern of nesting in early fin buds that includes HoxD14, a gene previously thought to be isolated from global Hox regulation. We also show that in both Polyodon and the catshark Scyliorhinus canicula (a representative chondrichthyan) late phase HoxD transcripts are present in cells of the fin-fold and co-localize with And1, a component of the dermal skeleton. These new data support an ancestral role for HoxD genes in patterning the fin-folds of jawed vertebrates, and fuel new hypotheses about the evolution of cluster regulation and the potential downstream differentiation outcomes of distinct HoxD-regulated compartments.
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