Evidence map›Paper›PMID 26940461›Full record

ArticleCell cycle (Georgetown, Tex.)2016

Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling.

Nannan Zhang, Zhongchi Li, Wei Mu, Liyuan Li, Yaru Liang, Maoyang Lu, Zhuoran Wang, Ying Qiu, Zhao Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 105 citations in OpenAlex.

  1. Review
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  10. Review
  11. Sirtuins in kidney health and disease.Nature reviews. Nephrology · 2024
    Review
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nannan Zhanga MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Zhongchi Lia MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Wei Mua MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Liyuan Lia MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Yaru Lianga MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Maoyang Lua MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Zhuoran Wanga MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Ying Qiua MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Zhao Wanga MOE Key Laboratory of Protein Sciences , Department of Pharmacology, School of Medicine, Tsinghua University , Beijing , P.R. China.
Tsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the sirtuin family of NAD(+)-dependent histone deacetylases, which is responsible for mediating the effects of CR. The transcription factor NF-κB, which is involved in inflammation and aging, has been shown to be regulated by SIRT6. Here we describe the crucial role of SIRT6 in aging and inflammation. We show that CR had improved renal insufficiency and enhanced SIRT6 expression after 6-month treatment in aged mice. Culture cells in low glucose (LG) conditions also showed resistance to cell senescence and enhanced SIRT6 expression compared to normal glucose (NG) group, showing beneficial effects of the CR-mimic cultural conditions. Moreover, SIRT6 overexpression is sufficient to delay the replicative senescence of WI38 by attenuating NF-κB signaling, while SIRT6 knockdown results in accelerated cell senescence and overactive NF-κB signaling. These findings confirm the key status of CR and disclose the critical role of SIRT6 on aging and inflammation.

Indexed as

Caloric RestrictionAgingAnimalsApoptosisCells, CulturedCellular SenescenceDNA ReplicationHumansInflammationMaleMice, Inbred C57BLNF-kappa BRenal InsufficiencySignal TransductionSirtuinsNF-kappa BSirt6 protein, mouseSirtuinsagingcalorie restrictioninflammationkidneyNF-κBp16SIRT6

Identifiers

PMID26940461
PMCPMC4889297
OpenAlexW2294654701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.