ArticleScientific reports2016
Fermented Sipjeondaebo-tang Alleviates Memory Deficits and Loss of Hippocampal Neurogenesis in Scopolamine-induced Amnesia in Mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Lactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes.Foods (Basel, Switzerland) · 2026Review
- Article
- Protective Effects of a Propolis-Journal of microbiology and biotechnology · 2026Article
- Therapeutic effects ofIBRO neuroscience reports · 2025Article
- Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice.Neurochemical research · 2025Article
- Studies on the Effects of Fermentation on the Phenolic Profile and Biological Activity of Three Cultivars of Kale.Molecules (Basel, Switzerland) · 2024Article
- Montelukast Ameliorates Scopolamine-induced Alzheimer's Disease: Role on Cholinergic Neurotransmission, Antioxidant Defence System, Neuroinflammation and Expression of BDNF.CNS & neurological disorders drug targets · 2024Article
- Neuroprotective effect ofHeliyon · 2023Article
- Effects of Phytochemicals from Fermented Food Sources in Alzheimer's Disease In Vivo Experimental Models: A Systematic Review.Foods (Basel, Switzerland) · 2023Review
- Neuroprotective effect of ranolazine improves behavioral discrepancies in a rat model of scopolamine-induced dementia.Frontiers in neuroscience · 2023Article
- Mitigating Effect ofMolecules (Basel, Switzerland) · 2021Article
- Scopolamine-Induced Memory Impairment in Mice: Neuroprotective Effects ofInternational journal of Alzheimer's disease · 2020Article
- Anti-dermatitic effect of fermented ginseng extract including rich compound K through inhibiting activation of macrophage.Food science and biotechnology · 2019Article
- Enhanced production of compound K in fermented ginseng extracts byFood science and biotechnology · 2019Article
- Enhancement of neuroprotective activity of Sagunja-tang by fermentation with lactobacillus strains.BMC complementary and alternative medicine · 2018Article
- Article
- Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury.Molecular neurobiology · 2018Article
- A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- The Requirement of L-Type Voltage-Dependent Calcium Channel (L-VDCC) in the Rapid-Acting Antidepressant-Like Effects of Scopolamine in Mice.The international journal of neuropsychopharmacology · 2018Article
- Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice.Evidence-based complementary and alternative medicine : eCAM · 2018Article
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Authors and funding
5 authors.
Funding
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Abstract
We investigated the anti-amnesic effects of SJ and fermented SJ (FSJ) on scopolamine (SCO)-induced amnesia mouse model. Mice were orally co-treated with SJ or FSJ (125, 250, and 500 mg/kg) and SCO (1 mg/kg), which was injected intraperitoneally for 14 days. SCO decreased the step-through latency and prolonged latency time to find the hidden platform in the passive avoidance test and Morris water maze test, respectively, and both SCO effects were ameliorated by FSJ treatment. FSJ was discovered to promote hippocampal neurogenesis during SCO treatment by increasing proliferation and survival of BrdU-positive cells, immature/mature neurons. In the hippocampus of SCO, oxidative stress and the activity of acetylcholinesterase were elevated, whereas the levels of acetylcholine and choline acetyltransferase were diminished; however, all of these alterations were attenuated by FSJ-treatment. The alterations in brain-derived neurotrophic factor, phosphorylated cAMP response element-binding protein, and phosphorylated Akt that occurred following SCO treatment were protected by FSJ administration. Therefore, our findings are the first to suggest that FSJ may be a promising therapeutic drug for the treatment of amnesia and aging-related or neurodegenerative disease-related memory impairment. Furthermore, the molecular mechanism by which FSJ exerts its effects may involve modulation of the cholinergic system and BDNF/CREB/Akt pathway.
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