ArticleMalaria journal2016
B cell sub-types following acute malaria and associations with clinical immunity.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Immunological correlates of mycobacterial growth inhibition describe a spectrum of tuberculosis infection.Scientific reports · 2018Trial
- Mechanistic interactions between Plasmodium falciparum and Epstein-Barr virus in endemic Burkitt Lymphoma pathogenesis: a narrative review (2010-2026).Infectious agents and cancer · 2026Review
- Malaria exposure history shapes PD-1 expression across human B-cell subsets during acute Plasmodium falciparum infection.BMC microbiology · 2026Article
- Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.PLoS pathogens · 2025Article
- Development of high affinity antibodies toFrontiers in immunology · 2025Article
- Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults.Scientific reports · 2024Article
- Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.Nature communications · 2023Article
- Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly.Cell reports · 2023Article
- Current understanding of the immune potential of B-cell subsets in malarial pathogenesis.Frontiers in microbiology · 2023Review
- IL-10 Producing Regulatory B Cells Mediated Protection against Murine Malaria Pathogenesis.Biology · 2022Article
- High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria.JCI insight · 2021Observational
- Immunological Considerations forFrontiers in immunology · 2021Review
- Generation of plasma cells and CD27Clinical & translational immunology · 2021Article
- Comparison of leucocyte profiles between healthy children and those with asymptomatic and symptomatic Plasmodium falciparum infections.Malaria journal · 2020Article
- Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response AgainstFrontiers in immunology · 2020Article
- Atypical memory B-cells are associated witheLife · 2019Article
- FCRL5Cell reports · 2019Article
- Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure.BMC medicine · 2019Article
- TFrontiers in immunology · 2019Review
- Development of B Cell Memory in Malaria.Frontiers in immunology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundRepeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria.
methodsTo better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria-lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia.
resultsAtypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria.
conclusionsThese findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.