ArticleAJNR. American journal of neuroradiology2016
Atypical Presentations of Intracranial Hypotension: Comparison with Classic Spontaneous Intracranial Hypotension.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Spontaneous intracranial hypotension: A stepwise diagnostic and therapeutic workflow from a tertiary referral center.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Hallmarks of headache disorders: part 5 - secondary headaches.The journal of headache and pain · 2026Review
- Spontaneous Intracranial Hypotension and CSF-Venous Fistulae: from Diagnostic Imaging to Interventional Management.Clinical neuroradiology · 2026Review
- Catheter-assisted sealing technique for spontaneous cerebrospinal fluid leaks: A novel neurointerventional treatment of spontaneous cerebrospinal fluid leak beyond cerebrospinal fluid-venous fistula.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Skull defect - Frontotemporal dementia sagging brain syndrome.Annals of clinical and translational neurology · 2025Article
- Spontaneous intracranial hypotension.Practical neurology · 2024Review
- Movement Disorders in Brain Sagging Syndrome Due To Spontaneous Intracranial Hypotension: A Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Brain Sagging Dementia.Current neurology and neuroscience reports · 2023Review
- Case report: Post-traumatic Tourette syndrome resolving with treatment of jugular venous narrowing; reconciling organic brain dysfunction following whiplash trauma with the absence of direct brain injury.Frontiers in neurology · 2023Article
- When does too little pressure become too much? A case of spontaneous intracranial hypotension presenting with acute loss of consciousness.Surgical neurology international · 2023Article
- [Spontaneous intracranial hypotension with brain sagging and reversible frontotemporal dementia : Case report and review of the literature].Der Nervenarzt · 2022Review
- The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Spontaneous intracranial hypotension: diagnostic and therapeutic workup.Neuroradiology · 2021Review
- Spontaneous intracranial hypotension presenting with progressive cognitive decline.BMJ case reports · 2021Article
- Article
- Intracranial Hypotension With Mild Parkinsonism and Bulbar Dysfunction.Neurology. Clinical practice · 2021Article
- The splenium of the corpus callosum: embryology, anatomy, function and imaging with pathophysiological hypothesis.Neuroradiology · 2020Review
- Spinal cerebrospinal fluid leak in the context of pars interarticularis fracture.BMC neurology · 2020Article
- Frontotemporal brain sagging syndrome: Craniospinal hypovolemia secondary to a T6-T7 cerebrospinal fluid-venous fistula.Surgical neurology international · 2020Article
- Assessing Spinal Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension With a Scoring System Based on Brain Magnetic Resonance Imaging Findings.JAMA neurology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAtypical clinical presentations of spontaneous intracranial hypotension include obtundation, memory deficits, dementia with frontotemporal features, parkinsonism, and ataxia. The purpose of this study was to compare clinical and imaging features of spontaneous intracranial hypotension with typical-versus-atypical presentations. MATERIALS AND
methodsClinical records and neuroimaging of patients with spontaneous intracranial hypotension from September 2005 to August 2014 were retrospectively evaluated. Patients with classic spontaneous intracranial hypotension (n = 33; mean age, 41.7 ± 14.3 years) were compared with those with intracranial hypotension with atypical clinical presentation (n = 8; mean age, 55.9 ± 14.1 years) and 36 controls (mean age, 41.4 ± 11.2 years).
resultsPatients with atypical spontaneous intracranial hypotension were older than those with classic spontaneous intracranial hypotension (55.9 ± 14.1 years versus 41.7 ± 14.3 years; P = .018). Symptom duration was shorter in classic compared with atypical spontaneous intracranial hypotension (3.78 ± 7.18 months versus 21.93 ± 18.43 months; P = .015). There was no significant difference in dural enhancement, subdural hematomas, or cerebellar tonsil herniation. Patients with atypical spontaneous intracranial hypotension had significantly more elongated anteroposterior midbrain diameter compared with those with classic spontaneous intracranial hypotension (33.6 ± 2.9 mm versus 27.3 ± 2.9 mm; P < .001) and shortened pontomammillary distance (2.8 ± 1 mm versus 5.15 ± 1.5 mm; P < .001). Patients with atypical spontaneous intracranial hypotension were less likely to become symptom-free, regardless of treatment, compared with those with classic spontaneous intracranial hypotension (χ(2) = 13.99, P < .001).
conclusionsIn this sample of 8 patients, atypical spontaneous intracranial hypotension was a more chronic syndrome compared with classic spontaneous intracranial hypotension, with more severe brain sagging, lower rates of clinical response, and frequent relapses. Awareness of atypical presentations of spontaneous intracranial hypotension is paramount.
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