SynthesisEpidemiology and infection2016
Case-fatality risk of pregnant women with acute viral hepatitis type E: a systematic review and meta-analysis.
Synthesis in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05808166 (A Phase II, Randomized, Observer-blinded, Placebo Controlled Trial to Evaluate the Safety and Immunogenicity of Hecolin® in Healthy Pregnant Women Between Gestational Age 14-34 Weeks and Non-Pregnant Women of 16-45 Years Old.), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II, Randomized, Observer-blinded, Placebo Controlled Trial to Evaluate the Safety and Immunogenicity of Hecolin® in Healthy Pregnant Women Between Gestational Age 14-34 Weeks and Non-Pregnant Women of 16-45 Years Old.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The burden of HEV-related acute liver failure in Bangladesh, China and India: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Estimating case fatality risk of severe Yellow Fever cases: systematic literature review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Immunogenicity and safety of co-administeredFrontiers in immunology · 2026Trial
- Seroprevalence of Hepatitis A Virus (HAV) and Hepatitis E Virus (HEV) Among Blood Donor Candidates in Salvador, Bahia, Brazil.Viruses · 2026Article
- From discovery to treatment: tracing the path of hepatitis E virus.Virology journal · 2024Review
- Confidential Enquiry into Maternal Deaths in Namibia, 2018-2019: A Local Approach to Strengthen the Review Process and a Description of Review Findings and Recommendations.Maternal and child health journal · 2023Review
- Review
- Hepatitis E vaccine-Illuminating the barriers to use.PLoS neglected tropical diseases · 2023Article
- Predicting incidence of hepatitis E using machine learning in Jiangsu Province, China.Epidemiology and infection · 2022Article
- Maternal and fetal outcomes of pregnancies complicated by acute hepatitis E and the impact of HIV status: A cross-sectional study in Namibia.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- The Foodborne Transmission of Hepatitis E Virus to Humans.Food and environmental virology · 2021Review
- Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus.Viruses · 2021Review
- Closer and closer? Maternal immunization: current promise, future horizons.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Common European Origin of Hepatitis E Virus in Human Population From Eastern Romania.Frontiers in public health · 2020Article
- Comprehensive analysis of genetic and evolutionary features of the hepatitis E virus.BMC genomics · 2019Article
- Genetic Variability and Evolution of Hepatitis E Virus.Viruses · 2019Review
- Hepatitis E virus: reasons for emergence in humans.Current opinion in virology · 2019Review
- Classification and Genomic Diversity of Enterically Transmitted Hepatitis Viruses.Cold Spring Harbor perspectives in medicine · 2018Review
- Reactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study.PLoS neglected tropical diseases · 2018Article
- Development of new hepatitis E vaccines.Human vaccines & immunotherapeutics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is of great concern that pregnant women with acute viral hepatitis (AVH) type E have serious consequences. This study aimed to estimate the case-fatality risk (CFR) and potential risk factors of pregnant women with AVH type E. We searched the PubMed, EMBASE, and Web of Science databases for studies containing data on CFR in pregnancy with AVH type E. A pooled estimate of CFR was calculated using a random-effects model. Potential sources of heterogeneity were explored using subgroup analysis, sensitivity analysis, and meta-regression. We identified 47 eligible studies with a total African and Asian population of 3968 individuals. The pooled CFRs of maternal and fetal outcomes were 20·8% [95% confidence interval (CI) 16·6-25·3] and 34·2% (95% CI 26·0-43·0), respectively. Compared with these, the pooled CFR was highest (61·2%) in women with fulminant hepatic failure (FHF). Community-based surveys had lower pooled CFR (12·2%, 95% CI 9·2-15·6) and heterogeneity (25·8%, 95% CI 20·1-32·0) than hospital-based surveys. Univariate analysis showed that hospital-based surveying (P = 0·007), and patients in the third trimester of pregnancy or with FHF (P < 0·05), were significantly associated with CFR. Intrauterine fetal mortality (27·0%) was statistically higher than neonatal mortality (3·9%). Control measures for HEV infection would reduce feto-maternal mortality in Asia and Africa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.