Evidence map›Paper›PMID 26939126›Full record

ArticlePloS one2016

Growth in Egg Yolk Enhances Salmonella Enteritidis Colonization and Virulence in a Mouse Model of Human Colitis.

Matthew R Moreau, Dona Saumya S Wijetunge, Megan L Bailey, Sudharsan R Gongati, Laura L Goodfield, Eranda Mangala K Kurundu Hewage, Mary J Kennett, Christine Fedorchuk, Yury V Ivanov, Jessica E Linder and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Comparative Patho-Genomics ofPathogens (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. The vertical transmission ofOne health (Amsterdam, Netherlands) · 2023
    Review
  6. Egg-associatedFrontiers in microbiology · 2023
    Article
  7. Article
  8. The Role of Egg Yolk in Modulating the Virulence ofFrontiers in cellular and infection microbiology · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Matthew R MoreauDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Dona Saumya S WijetungeDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Megan L BaileyDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Sudharsan R GongatiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Laura L GoodfieldDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Eranda Mangala K Kurundu HewageDepartment of Food Science, The Pennsylvania State University, University Park, PA, United States of America.
Mary J KennettDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Christine FedorchukDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Yury V IvanovDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Jessica E LinderDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Bhushan M JayaraoDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Subhashinie KariyawasamDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America.
Pennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salmonella Enteritidis (SE) is one of the most common causes of bacterial food-borne illnesses in the world. Despite the SE's ability to colonize and infect a wide-range of host, the most common source of infection continues to be the consumption of contaminated shell eggs and egg-based products. To date, the role of the source of SE infection has not been studied as it relates to SE pathogenesis and resulting disease. Using a streptomycin-treated mouse model of human colitis, this study examined the virulence of SE grown in egg yolk and Luria Bertani (LB) broth, and mouse feces collected from mice experimentally infected with SEE1 (SEE1 passed through mice). Primary observations revealed that the mice infected with SE grown in egg yolk displayed greater illness and disease markers than those infected with SE passed through mice or grown in LB broth. Furthermore, the SE grown in egg yolk achieved higher rates of colonization in the mouse intestines and extra-intestinal organs of infected mice than the SE from LB broth or mouse feces. Our results here indicate that the source of SE infection may contribute to the overall pathogenesis of SE in a second host. These results also suggest that reservoir-pathogen dynamics may be critical for SE's ability to establish colonization and priming for virulence potential.

Indexed as

Food MicrobiologyAnimalsChickensColitisDisease Models, AnimalEgg YolkEnzyme-Linked Immunosorbent AssayFecesHumansIntestinesMiceMice, Inbred C57BLSalmonella enteritidisSalmonella InfectionsSalmonella Infections, AnimalStreptomycinStreptomycin

Identifiers

PMID26939126
PMCPMC4777358
OpenAlexW2291286261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.