Evidence map›Paper›PMID 26938438›Full record

ArticleNeuron2016

The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition.

Geoffrey A Vargish, Chris J McBain

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Characterization of Effectiveness in ConcertedInternational journal of molecular sciences · 2020
    Article
  3. Opportunities for cannabis in supportive care in cancer.Therapeutic advances in medical oncology · 2019
    Review
  4. CBNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Geoffrey A VargishProgram in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Chris J McBainProgram in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: mcbainc@mail.nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Neuron, Maroso et al. (2016) describe a novel link between cannabinoids and cognition. They show that CB1Rs bidirectionally modulate HCN-mediated Ih in a subset of CA1 pyramidal neurons to influence both short- and long-term circuit dynamics and alter spatial working memory in behaving mice.

Indexed as

AnimalsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsReceptor, Cannabinoid, CB1Spatial MemorySynaptic PotentialsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsReceptor, Cannabinoid, CB1

Identifiers

PMID26938438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.