ArticlePloS one2016
Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
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- Emotional control in selected somatic and psychiatric diseases.BMC psychiatry · 2023Article
- A prospective study of the relative contribution of adolescent peer support quantity and quality to depressive symptoms.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Ways of Coping with Stress among Patients with Depressive Disorders.Journal of clinical medicine · 2022Article
- Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process.Translational psychiatry · 2022Article
- Effects of somatic treatments on suicidal ideation and completed suicides.Brain and behavior · 2021Review
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- TheFrontiers in genetics · 2021Article
- Suicidal ideation and aggression in childhood, genetic variation and young adult depression.Journal of affective disorders · 2020Article
- Evaluation of the role of stress in patients with breast cancer and depression by paykel's life event and adaptive neuro-fuzzy approach.Brain and behavior · 2020Article
- Gender Differences in Depression: Evidence From Genetics.Frontiers in genetics · 2020Review
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- "Out, out, brief candle! Life's but a walking shadow":Frontiers in psychiatry · 2020Article
- Dynamic interaction of genetic risk factors and cocaine abuse in the background of Parkinsonism - a case report.BMC neurology · 2019Article
- Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand.Behavior genetics · 2019Article
- Associations Between Adolescent Chronic Pain and Prescription Opioid Misuse in Adulthood.The journal of pain · 2019Article
- A direct test of the diathesis-stress model for depression.Molecular psychiatry · 2018Article
- Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats.Scientific reports · 2017Article
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe low transcriptionally efficient short-allele of the 5HTTLPR serotonin transporter polymorphism has been implicated to moderate the relationship between the experience of stressful life events (SLEs) and depression. Despite numerous attempts at replicating this observation, results remain inconclusive.
methodsWe examined this relationship in young-adult Non-Hispanic white males and females between the ages of 22 and 26 (n = 4724) participating in the National Longitudinal Study of Adolescent to Adult Health (Add Health) with follow-up information every six years since 1995.
resultsLinear and logistic regression models, corrected for multiple testing, indicated that carriers of one or more of the S-alleles were more sensitive to stress than those with two L-alleles and at a higher risk for depression. This relationship behaved in a dose-response manner such that the risk for depression was greatest among those who reported experiencing higher numbers of SLEs. In post-hoc analyses we were not able to replicate an interaction effect for suicide ideation but did find suggestive evidence that the effects of SLEs and 5HTTLPR on suicide ideation differed for males and females. There were no effects of childhood maltreatment. DISCUSSION: Our results provide partial support for the original hypothesis that 5-HTTLPR genotype interacts with the experience of stressful life events in the etiology of depression during young adulthood. However, even with this large sample, and a carefully constructed a priori analysis plan, the results were still not definitive. For the purposes of replication, characterizing the 5HTTLPR in other large data sets with extensive environmental and depression measures is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.