ArticleMedicine2016
Association Between Kidney Stones and Risk of Stroke: A Nationwide Population-Based Cohort Study.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta-analysis.Medicine · 2017Pooled it
- Association between kidney stones and major adverse cardiovascular events: a population-based analysis.Urolithiasis · 2026Article
- Oxalate as an Emerging Contributor to Cardiovascular Disease: Links to Inflammation, Immunity, and Oxidative Stress.Nutrients · 2026Review
- Kidney failure from kidney stones: an ANZDATA study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Between a Rock and a Short Place-The Impact of Nephrolithiasis on Skeletal Growth and Development Across the Lifespan.Current osteoporosis reports · 2024Review
- Proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats.BMC genomics · 2023Article
- Nephrolithiasis: A Red Flag for Cardiovascular Risk.Journal of clinical medicine · 2022Review
- Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers.Journal of personalized medicine · 2022Article
- Plasma oxalic acid and cardiovascular risk in end-stage renal disease patients: a prospective, observational cohort pilot study.The Korean journal of internal medicine · 2022Observational
- Stone extraction with loop ureteral catheter versus ureteroscopy in small distal ureteral stones-retrospective comparison of 547 consecutive patients.Translational andrology and urology · 2021Article
- Ectopic biomineralization in kidney stone formers compared to non-stone formers.Translational andrology and urology · 2020Article
- Decreased Risk of Renal Calculi in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer.International journal of environmental research and public health · 2020Article
- Nephrolithiasis predicts ischemic stroke: A longitudinal follow-up study using a national sample cohort.International journal of medical sciences · 2019Article
- Urinary Stone Disease and Cardiovascular Disease Risk in a Rural Chinese Population.Kidney international reports · 2017Article
- Article
- Increasing risk of cataract in HCV patients receiving anti-HCV therapy: A nationwide cohort study.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrolithiasis is highly prevalent and has been associated with vascular diseases such as cardiovascular events. Few studies have comprehensively associated renal stones with stroke.This study explored whether patients with renal stones were at a higher stroke risk than those without renal stones. A national insurance claim dataset of 22 million enrollees in Taiwan was used to identify 53,659 patients with renal stones, and 214,107 were selected as age-, sex-, and comorbidity-matched controls for a 13-year follow-up.The relative stroke risk for the RS cohort was 1.06-fold higher than that for the non-RS group (95% confidence interval [CI] = 1.01-1.11). Age-specific analysis revealed that the adjusted stroke risk for the RS cohort increased as age decreased, with the highest risk of 1.47-fold (95% CI = 1.10-1.96) in patients aged 20 to 34 years, followed by a 1.12-fold risk (95% CI = 1.00-1.25) in patients aged 35 to 50 years. Sex-specific analysis clarified that women in the RS group had a 1.12-fold stroke risk compared with women in the non-RS group (95% CI = 1.03-1.21). Patients who had undergone >4 surgeries had up to 42.5-fold higher risk of stroke (95% CI = 33.8-53.4).The study utilized the national database and demonstrated that patients, particularly women and the younger population, with nephrolithiasis have an increased risk of ischemic stroke development. Patients treated with medication or through surgery for RSs showed steady and higher risks of stroke than those without surgical or medical intervention.
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Registered trials
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