Observational studyMedicine2016
Serum Calcium Increase Correlates With Worsening of Lipid Profile: An Observational Study on a Large Cohort From South Italy.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- Association of serum essential and non-essential elements with dyslipidemia in patients with cardiovascular disease in Western Iran: an application of Bayesian kernel machine regression.BMC cardiovascular disorders · 2026Article
- Alterations in serum levels of calcium, vitamin D, phosphorus, and parathyroid hormone in patients with clinically confirmed familial hypercholesterolemia: a cross-sectional study.Annals of medicine and surgery (2012) · 2024Article
- Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice.FEBS open bio · 2024Article
- Association of the serum calcium level with metabolic syndrome and its components among adults in Taiwan.Archives of endocrinology and metabolism · 2023Article
- Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism.Journal of clinical medicine · 2022Article
- Silencing acetyl-CoA carboxylase A and sterol regulatory element-binding protein 1 genes through RNAi reduce serum and egg cholesterol in chicken.Scientific reports · 2022Article
- Corrected Serum Ionized Calcium as a Risk Factor Related to Adult Dyslipidemia.Frontiers in cardiovascular medicine · 2022Article
- Carotid-femoral pulse wave velocity is significantly increased in newly diagnosed hypertensive patients with primary hyperparathyroidism and significantly related with serum calcium level.Journal of ultrasound · 2021Article
- Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3-5 chronic kidney disease patients in Taiwan.BMC nephrology · 2021Article
- Temporal Relationship Between Changes in Serum Calcium and Hypercholesteremia and Its Impact on Future Brachial-Ankle Pulse Wave Velocity Levels.Frontiers in nutrition · 2021Article
- The Role of Serum Calcium Levels in Pediatric Dyslipidemia: Are There Any?Frontiers in pediatrics · 2021Article
- Association between Serum Calcium and Risk of Cardiometabolic Disease among Community-dwelling Adults in Taiwan.Scientific reports · 2020Article
- Development and validation of a multivariate predictive model to estimate serum ionized calcium concentration from serum biochemical profile results in cats.Journal of veterinary internal medicine · 2019Article
- Borderline high serum calcium levels are associated with arterial stiffness and 10-year cardiovascular disease risk determined by Framingham risk score.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Dietary calcium status during maternal pregnancy and lactation affects lipid metabolism in mouse offspring.Scientific reports · 2018Article
- Higher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals.Korean journal of family medicine · 2018Article
- Association of bone metabolism markers with coronary atherosclerosis and coronary artery disease in postmenopausal women.Journal of bone and mineral metabolism · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the well-documented role of calcium in cell metabolism, its role in the development of cardiovascular disease is still under heavy debate. Several studies suggest that calcium supplementation might be associated with an increased risk of coronary heart disease, whereas others underline a significant effect on lowering high blood pressure and hyperlipidemia. The purpose of this study was to investigate, in a large nonselected cohort from South Italy, if serum calcium levels correlate with lipid values and can therefore be linked to higher individual cardiovascular risk.Eight-thousand-six-hundred-ten outpatients addressed to the Laboratory of Clinical Biochemistry, University of Magna Græcia, Catanzaro, Italy from January 2012 to December 2013 for routine blood tests, were enrolled in the study. Total HDL-, LDL- and non-HDL colesterol, triglycerides, and calcium were determined with standard methods.We observed a significant association between total cholesterol, LDL-cholesterol, HDL-cholesterol, non-HDL cholesterol, triglycerides, and serum calcium in men and postmenopause women. Interestingly, in premenopause women, we only found a direct correlation between serum calcium, total cholesterol, and HDL-cholesterol. Calcium significantly increased while increasing total cholesterol and triglycerides in men and postmenopause women.Our results confirm that progressive increase of serum calcium level correlates with worsening of lipid profile in our study population. Therefore, we suggest that a greater caution should be used in calcium supplement prescription particularly in men and women undergoing menopause, in which an increase of serum lipids is already known to be associated with a higher cardiovascular risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.