Evidence map›Paper›PMID 26937443›Full record

ArticleEuropean journal of radiology open2015

Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology.

Peter de Boer, Maaike C G Bleeker, Anje M Spijkerboer, Agustinus J A J van de Schoot, Shandra Bipat, Marrije R Buist, Coen R N Rasch, Jaap Stoker, Lukas J A Stalpers

Abstract read
In one paragraph

Article in European journal of radiology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy : A comparison of benefits.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter de BoerDepartment of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Maaike C G BleekerDepartment of Pathology, AMC, UvA, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Anje M SpijkerboerDepartment of Radiology, AMC, UvA, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Agustinus J A J van de SchootDepartment of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Shandra BipatDepartment of Radiology, AMC, UvA, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Marrije R BuistDepartment of Gynaecologic Oncology, AMC, UvA, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Coen R N RaschDepartment of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Jaap StokerDepartment of Radiology, AMC, UvA, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Lukas J A StalpersDepartment of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer. MATERIALS AND

methodsAfter approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.

resultsMedian craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.

conclusionMRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

Indexed as

AccuracyCI, confidence intervalCraniocaudalCRF, case record formCTV, clinical target volumeEBRT, external beam radiation therapyESTRO, European society of therapeutic radiology and oncologyExtensionFIGO, international federation of gynaecology and obstetricsICC, intraclass correlation coefficientJCOG, Japan clinical oncology groupLLETZ, large loop excision of the transformation zoneMRIMRI, magnetic resonance imagingNCIC, national cancer institute of CanadaPTV, planning target volumeRT, radiation therapySD, standard deviationUterine cervical cancerVMAT, volumetric modulated arc therapy

Identifiers

PMID26937443
PMCPMC4750554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.