Evidence map›Paper›PMID 26937378›Full record

ArticleNeuroImage. Clinical2016

Delay of cognitive gamma responses in Alzheimer's disease.

Erol Başar, Derya Durusu Emek-Savaş, Bahar Güntekin, Görsev G Yener

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erol BaşarBrain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey. Electronic address: e.basar@iku.edu.tr.
Derya Durusu Emek-SavaşBrain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey; Department of Psychology, Dokuz Eylül University, Izmir 35160, Turkey; Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey.
Bahar GüntekinBrain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey.
Görsev G YenerBrain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey; Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir 35340, Turkey; Department of Neurology, Dokuz Eylül University Medical School, Izmir 35340, Turkey.
Istanbul Kültür University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Event-related oscillations (EROs) reflect cognitive brain dynamics, while sensory-evoked oscillations (SEOs) reflect sensory activities. Previous reports from our lab have shown that those with Alzheimer's disease (AD) or mild cognitive impairment (MCI) have decreased activity and/or coherence in delta, theta, alpha and beta cognitive responses. In the current study, we investigated gamma responses in visual SEO and ERO in 15 patients with AD and in 15 age-, gender- and education-matched healthy controls. The following parameters were analyzed over the parietal-occipital regions in both groups: (i) latency of the maximum gamma response over a 0-800 ms time window; (ii) the maximum peak-to-peak amplitudes for each participant's averaged SEO and ERO gamma responses in 3 frequency ranges (25-30, 30-35, 40-48 Hz); and (iii) the maximum peak-to-peak amplitudes for each participant's averaged SEO and ERO gamma responses over a 0-800 ms time block containing four divided time windows (0-200, 200-400, 400-600, and 600-800 ms). There were main group effects in terms of both latency and peak-to-peak amplitudes of gamma ERO. However, peak-to-peak gamma ERO amplitude differences became noticeable only when the time block was divided into four time windows. SEO amplitudes in the 25-30 Hz frequency range of the 0-200 ms time window over the left hemisphere were greater in the healthy controls than in those with AD. Gamma target ERO latency was delayed up to 138 ms in AD patients when compared to healthy controls. This finding may be an effect of lagged neural signaling in cognitive circuits, which is reflected by the delayed gamma responses in those with AD. Based on the results of this study, we propose that gamma responses should be examined in a more detailed fashion using multiple frequency and time windows.

Indexed as

AdolescentAdultAgedAged, 80 and overAlzheimer DiseaseBrain WavesCognitionCognitive DysfunctionElectroencephalographyFemaleHumansMaleMiddle AgedPhotic StimulationYoung AdultAlzheimer's diseaseEEGEvent-relatedGammaOscillationP300Sensory-evoked

Identifiers

PMID26937378
PMCPMC4753813
OpenAlexW2299594799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.