ArticleZoological letters2016
Distal-less induces elemental color patterns in Junonia butterfly wings.
Article in Zoological letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
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- Eyespot variation and field temperature in the Meadow Brown butterfly.Ecology and evolution · 2024Article
- High-quality haploid genomes corroborate 29 chromosomes and highly conserved synteny of genes in Hyles hawkmoths (Lepidoptera: Sphingidae).BMC genomics · 2023Article
- Protein Delivery to Insect Epithelial Cells In Vivo: Potential Application to Functional Molecular Analysis of Proteins in Butterfly Wing Development.Biotech (Basel (Switzerland)) · 2023Article
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- Butterfly eyespot color pattern formation requires physical contact of the pupal wing epithelium with extracellular materials for morphogenic signal propagation.BMC developmental biology · 2020Article
- Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process.Development (Cambridge, England) · 2019Article
- Real-Time In Vivo Imaging of the Developing Pupal Wing Tissues in the Pale Grass Blue ButterflyJournal of imaging · 2019Article
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- Developmental dynamics of butterfly wings: real-time in vivo whole-wing imaging of twelve butterfly species.Scientific reports · 2018Article
- Phenotypic Nonspecificity as the Result of Limited Specificity of Transcription Factor Function.Genetics research international · 2018Review
- Wound healing, calcium signaling, and other novel pathways are associated with the formation of butterfly eyespots.BMC genomics · 2017Article
- Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns.Nature communications · 2016Article
- Focusing on butterfly eyespot focus: uncoupling of white spots from eyespot bodies in nymphalid butterflies.SpringerPlus · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe border ocellus, or eyespot, is a conspicuous color pattern element in butterfly wings. For two decades, it has been hypothesized that transcription factors such as Distal-less (Dll) are responsible for eyespot pattern development in butterfly wings, based on their expression in the prospective eyespots. In particular, it has been suggested that Dll is a determinant for eyespot size. However, functional evidence for this hypothesis has remained incomplete, due to technical difficulties.
resultsHere, we show that ectopically expressed Dll induces ectopic elemental color patterns in the adult wings of the blue pansy butterfly, Junonia orithya (Lepidoptera, Nymphalidae). Using baculovirus-mediated gene transfer, we misexpressed Dll protein fused with green fluorescent protein (GFP) in pupal wings, resulting in ectopic color patterns, but not the formation of intact eyespots. Induced changes included clusters of black and orange scales (a basic feature of eyespot patterns), black and gray scales, and inhibition of cover scale development. In contrast, ectopic expression of GFP alone did not induce any color pattern changes using the same baculovirus-mediated gene transfer system.
conclusionsThese results suggest that Dll plays an instructive role in the development of color pattern elements in butterfly wings, although Dll alone may not be sufficient to induce a complete eyespot. This study thus experimentally supports the hypothesis of Dll function in eyespot development.
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