ReviewImmune network2016
Induction of CD4(+) Regulatory and Polarized Effector/helper T Cells by Dendritic Cells.
Review in Immune network, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
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- Molecular Mechanism of VSV-Vectored ASFV Vaccine Activating Immune Response in DCs.Veterinary sciences · 2025Article
- Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges.Acta pharmaceutica Sinica. B · 2024Review
- Factor of time in dendritic cell (DC) maturation: short-term activation of DCs significantly improves type 1 cytokine production and T cell responses.Journal of translational medicine · 2024Article
- Article
- Effects of different inhalant allergens on lung functions in adult patients with bronchial asthma.Immunity, inflammation and disease · 2023Article
- Fingolimod protects against experimental necrotizing enterocolitis by regulating intestinal T cell differentiation.Translational pediatrics · 2022Article
- Immune modulation after traumatic brain injury.Frontiers in medicine · 2022Review
- Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review.Life (Basel, Switzerland) · 2021Review
- Granulocyte Macrophage-Colony Stimulating Factor Produces a Splenic Subset of Monocyte-Derived Dendritic Cells That Efficiently Polarize T Helper Type 2 Cells in Response to Blood-Borne Antigen.Frontiers in immunology · 2021Article
- Article
- EdibleNutrients · 2020Article
- Peptides from allergenic lipocalins bind to formyl peptide receptor 3 in human dendritic cells to mediate TThe Journal of allergy and clinical immunology · 2020Article
- Cellular Immune Response against NontypeableInfection and immunity · 2019Article
- Myeloid and Plasmacytoid Dendritic Cells and Cancer - New Insights.Open access Macedonian journal of medical sciences · 2019Review
- Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity.Cell death & disease · 2019Article
- Differential Responses of Human Dendritic Cells to Live or InactivatedFrontiers in immunology · 2019Article
- Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells.Yonsei medical journal · 2018Review
- Benefit of Apabetalone on Plasma Proteins in Renal Disease.Kidney international reports · 2018Article
- Glucocorticoid-Induced Leucine Zipper: Fine-Tuning of Dendritic Cells Function.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are considered to play major roles during the induction of T cell immune responses as well as the maintenance of T cell tolerance. Naive CD4(+) T cells have been shown to respond with high plasticity to signals inducing their polarization into effector/helper or regulatory T cells. Data obtained from in vitro generated bone-marrow (BM)-derived DCs as well as genetic mouse models revealed an important but not exclusive role of DCs in shaping CD4(+) T cell responses. Besides the specialization of some conventional DC subsets for the induction of polarized immunity, also the maturation stage, activation of specialized transcription factors and the cytokine production of DCs have major impact on CD4(+) T cells. Since in vitro generated BM-DCs show a high diversity to shape CD4(+) T cells and their high similarity to monocyte-derived DCs in vivo, this review reports data mainly on BM-DCs in this process and only touches the roles of transcription factors or of DC subsets, which have been discussed elsewhere. Here, recent findings on 1) the conversion of naive into anergic and further into Foxp3(-) regulatory T cells (Treg) by immature DCs, 2) the role of RelB in steady state migratory DCs (ssmDCs) for conversion of naive T cells into Foxp3(+) Treg, 3) the DC maturation signature for polarized Th2 cell induction and 4) the DC source of IL-12 for Th1 induction are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.