ArticleJournal of cereal science2016
Improving wheat to remove coeliac epitopes but retain functionality.
Article in Journal of cereal science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 121 citations in OpenAlex.
- Wheat in 2025: challenges for sustainable production and consumption.Journal of experimental botany · 2026Review
- CRISPR-based editing of the ω- and γ-gliadin gene clusters reduces wheat immunoreactivity without affecting grain protein quality.Plant biotechnology journal · 2024Article
- Breeding in bread-making wheat varieties for Mediterranean climate: the need to get resilient varieties.Frontiers in nutrition · 2024Article
- Integrating genomics and genome editing for orphan crop improvement: a bridge between orphan crops and modern agriculture system.GM crops & food · 2023Review
- Preparation and Characterization of Ferulic Acid Wheat Gluten Nanofiber Films with Excellent Antimicrobial Properties.Foods (Basel, Switzerland) · 2023Article
- Quality and Agronomic Trait Analyses of Pyramids Composed of Wheat GenesInternational journal of molecular sciences · 2023Article
- Does sourdough bread provide clinically relevant health benefits?Frontiers in nutrition · 2023Review
- Promoter DNA hypermethylation ofJournal of advanced research · 2022Article
- Genome-wide identification, characteristics and expression of the prolamin genes in Thinopyrum elongatum.BMC genomics · 2021Review
- Article
- A Case Study of the Response of Immunogenic Gluten Peptides to Sourdough Proteolysis.Nutrients · 2021Article
- Exploring the alpha-gliadin locus: the 33-mer peptide with six overlapping coeliac disease epitopes in Triticum aestivum is derived from a subgroup of Aegilops tauschii.The Plant journal : for cell and molecular biology · 2021Article
- Do modern types of wheat have lower quality for human health?Nutrition bulletin · 2020Review
- Comprehensive Comparison of Clinically Relevant Grain Proteins in Modern and Traditional Bread Wheat Cultivars.International journal of molecular sciences · 2020Article
- Genomic and functional genomics analyses of gluten proteins and prospect for simultaneous improvement of end-use and health-related traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity.Frontiers in nutrition · 2020Review
- Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them.Frontiers in nutrition · 2020Review
- Modified acid-PAGE method for rapid screening and phenotyping of wheat gliadin mutant lines.MethodsX · 2020Article
- Further Steps Toward the Development of Gluten Reference Materials - Wheat Flours or Protein Isolates?Frontiers in plant science · 2020Article
- Mapping Coeliac Toxic Motifs in the Prolamin Seed Storage Proteins of Barley, Rye, and Oats Using a Curated Sequence Database.Frontiers in nutrition · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coeliac disease is an intolerance triggered by the ingestion of wheat gluten proteins. It is of increasing concern to consumers and health professionals as its incidence appears to be increasing. The amino acid sequences in gluten proteins that are responsible for triggering responses in sensitive individuals have been identified showing that they vary in distribution among and between different groups of gluten proteins. Conventional breeding may therefore be used to select for gluten protein fractions with lower contents of coeliac epitopes. Molecular breeding approaches can also be used to specifically down-regulate coeliac-toxic proteins or mutate coeliac epitopes within individual proteins. A combination of these approaches may therefore be used to develop a "coeliac-safe" wheat. However, this remains a formidable challenge due to the complex multigenic control of gluten protein composition. Furthermore, any modified wheats must retain acceptable properties for making bread and other processed foods. Not surprisingly, such coeliac-safe wheats have not yet been developed despite over a decade of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.