ArticleJournal of neurophysiology2016
Effects of aging on the response of single neurons to amplitude-modulated noise in primary auditory cortex of rhesus macaque.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Aging effects on dual-route speech processing networks during speech perception in noise.Human brain mapping · 2024Article
- BOLD fMRI responses to amplitude-modulated sounds across age in adult listeners.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.Neurobiology of aging · 2022Article
- The Representation of Time Windows in Primate Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes.Aging cell · 2022Article
- Age-related hearing loss is associated with alterations in temporal envelope processing in different neural generators along the auditory pathway.Frontiers in neurology · 2022Article
- Hearing loss and brain plasticity: the hyperactivity phenomenon.Brain structure & function · 2021Review
- Peripheral deficits and phase-locking declines in aging adults.Hearing research · 2021Article
- Amplitude modulation encoding in the auditory cortex: comparisons between the primary and middle lateral belt regions.Journal of neurophysiology · 2020Article
- Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Objective evidence of temporal processing deficits in older adults.Hearing research · 2020Review
- Exaggerated cortical representation of speech in older listeners: mutual information analysis.Journal of neurophysiology · 2020Article
- Article
- Age-related changes in sound onset and offset intensity coding in auditory cortical fields A1 and CL of rhesus macaques.Journal of neurophysiology · 2020Article
- Temporal Coding of Single Auditory Nerve Fibers Is Not Degraded in Aging Gerbils.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Effects of Ketamine Administration on Auditory Information Processing in the Neocortex of Nonhuman Primates.Frontiers in psychiatry · 2020Article
- Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation.Neuroscience · 2019Review
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2 authors at 1 institution in 1 country.
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Abstract
Temporal envelope processing is critical for speech comprehension, which is known to be affected by normal aging. Whereas the macaque is an excellent animal model for human cerebral cortical function, few studies have investigated neural processing in the auditory cortex of aged, nonhuman primates. Therefore, we investigated age-related changes in the spiking activity of neurons in primary auditory cortex (A1) of two aged macaque monkeys using amplitude-modulated (AM) noise and compared these responses with data from a similar study in young monkeys (Yin P, Johnson JS, O'Connor KN, Sutter ML. J Neurophysiol 105: 582-600, 2011). For each neuron, we calculated firing rate (rate code) and phase-locking using phase-projected vector strength (temporal code). We made several key findings where neurons in old monkeys differed from those in young monkeys. Old monkeys had higher spontaneous and driven firing rates, fewer neurons that synchronized with the AM stimulus, and fewer neurons that had differential responses to AM stimuli with both a rate and temporal code. Finally, whereas rate and temporal tuning functions were positively correlated in young monkeys, this relationship was lost in older monkeys at both the population and single neuron levels. These results are consistent with considerable evidence from rodents and primates of an age-related decrease in inhibition throughout the auditory pathway. Furthermore, this dual coding in A1 is thought to underlie the capacity to encode multiple features of an acoustic stimulus. The apparent loss of ability to encode AM with both rate and temporal codes may have consequences for stream segregation and effective speech comprehension in complex listening environments.
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