ArticleJournal of neurophysiology2016
Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Late IMedicinal research reviews · 2026Review
- Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment.The Journal of comparative neurology · 2026Article
- Functional contributions of quantal and non-quantal hair cell synaptic transmission in the vestibular periphery.bioRxiv : the preprint server for biology · 2025Article
- A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.Communications biology · 2024Article
- Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci.International journal of molecular sciences · 2024Article
- Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.Frontiers in neurology · 2024Article
- Review
- Isolating and Culturing Vestibular and Spiral Ganglion Somata from Neonatal Rodents for Patch-Clamp Recordings.Journal of visualized experiments : JoVE · 2023Article
- Similarities in the Biophysical Properties of Spiral-Ganglion and Vestibular-Ganglion Neurons in Neonatal Rats.Frontiers in neuroscience · 2021Article
- Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021Article
- Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear.Frontiers in neuroscience · 2021Article
- Activation of GABAJournal of neurophysiology · 2020Article
- Persistent and resurgent NaJournal of neurophysiology · 2020Article
- Deletion of the CaFrontiers in cellular neuroscience · 2019Article
- Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7.Acta pharmacologica Sinica · 2018Article
- Regional and Developmental Differences in NaFrontiers in cellular neuroscience · 2018Article
- Accumulation of KThe Journal of physiology · 2017Article
- Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function.Frontiers in neurology · 2017Review
- Article
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Authors and funding
6 authors.
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Abstract
Firing patterns differ between subpopulations of vestibular primary afferent neurons. The role of sodium (NaV) channels in this diversity has not been investigated because NaV currents in rodent vestibular ganglion neurons (VGNs) were reported to be homogeneous, with the voltage dependence and tetrodotoxin (TTX) sensitivity of most neuronal NaV channels. RT-PCR experiments, however, indicated expression of diverse NaV channel subunits in the vestibular ganglion, motivating a closer look. Whole cell recordings from acutely dissociated postnatal VGNs confirmed that nearly all neurons expressed NaV currents that are TTX-sensitive and have activation midpoints between -30 and -40 mV. In addition, however, many VGNs expressed one of two other NaV currents. Some VGNs had a small current with properties consistent with NaV1.5 channels: low TTX sensitivity, sensitivity to divalent cation block, and a relatively negative voltage range, and some VGNs showed NaV1.5-like immunoreactivity. Other VGNs had a current with the properties of NaV1.8 channels: high TTX resistance, slow time course, and a relatively depolarized voltage range. In two NaV1.8 reporter lines, subsets of VGNs were labeled. VGNs with NaV1.8-like TTX-resistant current also differed from other VGNs in the voltage dependence of their TTX-sensitive currents and in the voltage threshold for spiking and action potential shape. Regulated expression of NaV channels in primary afferent neurons is likely to selectively affect firing properties that contribute to the encoding of vestibular stimuli.
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